Product Name
Seipin (Bscl2), Recombinant Protein
Full Product Name
Recombinant Rat Seipin (Bscl2)
Product Gene Name
Bscl2 recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-377aa; full length protein
Sequence
MVNDPPVPAL LWAQEVGHVL AGRARRLMLQ FGVLFCTILL LLWVSVFLYG SFYYSYMPTV SHLSPVHFYY RTDCDSSTAS LCSFPVANVS LTKSGRDRVL MYGQPYRVTL ELELPESPVN QDLGMFLVTV SCYTRGGRII STSSRSVMLH YRSQLLQMLD TLVFSSLLLF GFAEQKQLLE VELYSDYREN SYVPTTGAII EVHSKRVQMY GAYLRIHAHF TGLRYLLYNF PMTCAFVGVA SNFTFLSVIA LFSYMQWVWG AVWPRHRFSL QVNIRQRDNS GHGAQRRISR HQPGQASTQQ SDVTEDGESP EDPSGTEGQL SEEEKPEKQP LNGEGEQEPE ASDGSWEDAA LLTEASTSAL APETLGSLRQ RQTCSSS
3D Structure
ModBase 3D Structure for Q5FVJ6
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Bscl2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Bscl2 recombinant protein
Transmembrane Protein
Application Notes for Bscl2 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Bscl2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001012171.1
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NCBI GenBank Nucleotide #
NM_001012171.1
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UniProt Primary Accession #
Q5FVJ6
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UniProt Related Accession #
Q5FVJ6[Other Products]
Molecular Weight
42,409 Da
NCBI Official Full Name
seipin
NCBI Official Synonym Full Names
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
NCBI Official Symbol
Bscl2??[Similar Products]
NCBI Protein Information
seipin
UniProt Protein Name
Seipin
UniProt Synonym Protein Names
Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog
UniProt Gene Name
Bscl2??[Similar Products]
UniProt Entry Name
BSCL2_RAT
UniProt Comments for Bscl2
BSCL2: Is a regulator of lipid catabolism essential for adipocyte differentiation. Necessary for correct lipid storage and lipid droplets maintenance. Defects in BSCL2 are the cause of congenital generalized lipodystrophy type 2 (CGL2). Congenital generalized lipodystrophy is an autosomal recessive disorder characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. Defects in BSCL2 are the cause of spastic paraplegia type 17 (SPG17); also known as Silver spastic paraplegia syndrome. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. SPG17 is characterized by prominent amyotrophy of the hand muscles, the presence of mild to severe pyramidal tract signs, and spastic paraplegia. SPG17 is a motor neuron disease overlapping with distal spinal muscular atrophy type 5. Defects in BSCL2 are a cause of distal hereditary motor neuronopathy type 5A (HMN5A); also known as distal hereditary motor neuropathy type V (DSMAV). A disorder characterized by distal muscular atrophy mainly affecting the upper extremities, in contrast to other distal motor neuronopathies. These constitute a heterogeneous group of neuromuscular diseases caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. Belongs to the seipin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: integral to endoplasmic reticulum membrane
Biological Process: fat cell differentiation; lipid catabolic process; negative regulation of lipid catabolic process; sequestering of lipid
Research Articles on Bscl2
1. Localization, cDNA sequence and genomic organization of the rat and sequence analysis in inbred rat models of Type 2 diabetes mellitus.
Precautions
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Disclaimer
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