Potassium voltage-gated channel subfamily E member 2; MinK-related peptide 1; Minimum potassium ion channel-related peptide 1; Potassium channel subunit beta MiRP1; KCNE2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This KCNE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the C-terminal region of human KCNE2.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.33 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-KCNE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Voltage-gated potassium (Kv) channels represent the most
complex class of voltage-gated ion channels from both functional
and structural standpoints. Their diverse functions include
regulating neurotransmitter release, heart rate, insulin secretion,
neuronal excitability, epithelial electrolyte transport, smooth
muscle contraction, and cell volume. This gene encodes a member of
the potassium channel, voltage-gated, isk-related subfamily. This
member is a small integral membrane subunit that assembles with the
KCNH2 gene product, a pore-forming protein, to alter its function.
This gene is expressed in heart and muscle and the gene mutations
are associated with cardiac arrhythmia.

Cardiovascular; Neuroscience

Western Blot (WB), ELISA (EIA)

WB~~1:1000

KCNE2 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the KCNE2 antibody detected the KCNE2 protein (arrow).

14472

potassium channel, voltage gated subfamily E regulatory beta subunit 2

potassium voltage-gated channel subfamily E member 2

Potassium voltage-gated channel subfamily E member 2

KCNE2_HUMAN

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]

KCNE2: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current. Defects in KCNE2 are the cause of long QT syndrome type 6 (LQT6). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. KCNE2 mutants form channels that open slowly and close rapidly, thereby diminishing potassium currents. Defects in KCNE2 are the cause of familial atrial fibrillation type 4 (ATFB4). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the potassium channel KCNE family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.12

Cellular Component: voltage-gated potassium channel complex; cell surface; lysosome; plasma membrane

Molecular Function: protein homodimerization activity; potassium channel regulator activity; delayed rectifier potassium channel activity; inward rectifier potassium channel activity

Biological Process: tongue development; potassium ion import; aging

Disease: Long Qt Syndrome 6; Atrial Fibrillation, Familial, 4

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Albert, C.M., et al. Circ Arrhythm Electrophysiol 3(3):222-229(2010)
Subbiah, R.N., et al. Can J Cardiol 26(4):208-212(2010)
Tam, G.W., et al. Biochem. Soc. Trans. 38(2):445-451(2010)
Roepke, T.K., et al. PLoS ONE 5 (7), E11451 (2010) :

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.