Full Product Name
KCNH1 Polyclonal Antibody
Product Gene Name
anti-KCNH1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Other Notes
Small volumes of anti-KCNH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for KCNH1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002229.1
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NCBI GenBank Nucleotide #
NM_002238.3
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UniProt Secondary Accession #
O76035; Q14CL3; B1AQ26[Other Products]
UniProt Related Accession #
O95259[Other Products]
Molecular Weight
108,597 Da
NCBI Official Full Name
potassium voltage-gated channel subfamily H member 1 isoform 2
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily H member 1
NCBI Official Symbol
KCNH1??[Similar Products]
NCBI Official Synonym Symbols
EAG; EAG1; ZLS1; TMBTS; h-eag; hEAG1; Kv10.1
??[Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily H member 1
UniProt Protein Name
Potassium voltage-gated channel subfamily H member 1
UniProt Synonym Protein Names
Ether-a-go-go potassium channel 1
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNH1??[Similar Products]
UniProt Synonym Gene Names
; h-eag; hEAG1??[Similar Products]
NCBI Summary for KCNH1
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNH1
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9738473, PubMed:11943152, PubMed:10880439, PubMed:22732247, PubMed:25556795, PubMed:27325704, PubMed:27005320, PubMed:27618660). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).
Research Articles on KCNH1
1. A role of Kv10.1 in coordinating primary cilium disassembly with cell cycle progression through localized changes of membrane potential at the ciliary base is proposed [REVIEW].
Precautions
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Disclaimer
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