Full Product Name
KCNH2 Antibody
Product Synonym Names
Potassium voltage-gated channel subfamily H member 2; Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1; Voltage-gated potassium channel subunit Kv11.1; KCNH2; ERG; ERG1; HERG
Product Gene Name
anti-KCNH2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q12809
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Potassium voltage-gated channel subfamily H member 2 protein (894-1137AA)
Conjugation
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-KCNH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KCNH2 antibody
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (PubMed:18559421, PubMed:26363003, PubMed:27916661).
Product Categories/Family for anti-KCNH2 antibody
Neuroscience; Cardiovascular
Applications Tested/Suitable for anti-KCNH2 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-KCNH2 antibody
IHC: 1:20-1:200
IF: 1:50-1:200
Immunohistochemistry (IHC) of anti-KCNH2 antibody
Immunohistochemistry of paraffin-embedded human heart tissue using MBS7105237 at dilution of 1:100
Immunofluorescence (IF) of anti-KCNH2 antibody
Immunofluorescent analysis of HepG2 cells using MBS7105237 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
NCBI/Uniprot data below describe general gene information for KCNH2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000229.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000238.3
[Other Products]
UniProt Primary Accession #
Q12809
[Other Products]
UniProt Secondary Accession #
O75418; O75680; Q708S9; Q9BT72; Q9BUT7; Q9H3P0; A5H1P7; C4PFH9; D3DX04[Other Products]
UniProt Related Accession #
Q12809[Other Products]
Molecular Weight
115,636 Da
NCBI Official Full Name
potassium voltage-gated channel subfamily H member 2 isoform a
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily H member 2
NCBI Official Symbol
KCNH2??[Similar Products]
NCBI Official Synonym Symbols
ERG1; HERG; LQT2; SQT1; ERG-1; H-ERG; HERG1; Kv11.1
??[Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily H member 2
UniProt Protein Name
Potassium voltage-gated channel subfamily H member 2
UniProt Synonym Protein Names
Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1; Voltage-gated potassium channel subunit Kv11.1
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNH2??[Similar Products]
UniProt Synonym Gene Names
ERG; ERG1; HERG; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1??[Similar Products]
NCBI Summary for KCNH2
This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNH2
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (PubMed:18559421, PubMed:26363003, PubMed:27916661).
Research Articles on KCNH2
1. this study shows that hERG1 behaves as biomarker of progression to adenocarcinoma in Barrett's esophagus and can be exploited for a novel endoscopic surveillance
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
