Product Name
FILA, Polyclonal Antibody
Popular Item
Full Product Name
FILA Polyclonal Antibody
Product Synonym Names
Filaggrin; FLG
Product Gene Name
anti-FILA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P20930
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-FILA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-FILA antibody
Immunohistochemistry (IHC) Paraffin
Application Notes for anti-FILA antibody
IHC-p: 1:50-300
NCBI/Uniprot data below describe general gene information for FILA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002007.1
[Other Products]
NCBI GenBank Nucleotide #
NM_002016.1
[Other Products]
UniProt Primary Accession #
P20930
[Other Products]
UniProt Secondary Accession #
Q01720; Q5T583; Q9UC71[Other Products]
UniProt Related Accession #
P20930[Other Products]
NCBI Official Full Name
filaggrin
NCBI Official Synonym Full Names
filaggrin
NCBI Official Symbol
FLG??[Similar Products]
NCBI Official Synonym Symbols
ATOD2
??[Similar Products]
NCBI Protein Information
filaggrin
UniProt Protein Name
Filaggrin
UniProt Gene Name
FLG??[Similar Products]
NCBI Summary for FILA
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
UniProt Comments for FILA
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
Research Articles on FILA
1. This study demonstrated, for the first time, that FLG expression in UCB is associated with eczema development in infancy. Moreover, our analysis provided prediction models that were capable of discriminating, to a great extent, between those who will and will not develop eczema in infancy.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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