Anti -Caspase- (Pro-form) (caspase 6, apoptosis-related cysteine peptidase, Apoptotic protease Mch-2, CASP-6, MCH2)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 3R; NT_033777.2 (25625375..25627307). Location: 99C1-99C1

Monoclonal

IgG

9H214

Rabbit

Recognizes human pro-Caspase-6.

Supernatant
Supernatant

Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.

May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-Ice antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-6 is a major apoptotic executioner (1,2). It exists as a pro-domain protein and is cleaved by caspase-3 into two active subunits, an 18kD and a 10kD subunit (3). Caspase-6 cleaves among many different intracellular proteins, nuclear lamins. Lamins play a significant role in maintaining the integrity of the cell membrane, and their cleavage results in subsequent cellular breakdown and death (4).

Antibodies; Abs to Apoptosis, Caspase

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)

Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry.
Dilution: Western Blot: 1:10,000-1:20,000
Immunohistochemistry: 1:100-1:250
Immunocytochemistry: 1:100-1:250

37,363 Da[Similar Products]

CG7788 gene product from transcript CG7788-RA; CG7788-PA; Ice; Ice-PA; caspase-3; drice; interleukin-1beta-converting enzyme

Caspase

ICE_DROME

CASP7: Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro

Protein type: Endoplasmic reticulum; Mitochondrial; Apoptosis; EC 3.4.22.60; Protease

Cellular Component: cytoplasm

Molecular Function: cysteine-type endopeptidase activity

Biological Process: spermatid differentiation; sterol regulatory element binding protein cleavage; apoptosis; programmed cell death; regulation of retinal cell programmed cell death; nurse cell apoptosis; salivary gland histolysis; positive regulation of compound eye retinal cell programmed cell death; response to X-ray; neuron remodeling

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