For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG2a

BB1E2

Mouse

Purified
Purified IgG - liquid

IgG concentration 1.0 mg/ml (lot specific)

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Small volumes of anti-CD119 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Mouse anti Human CD119 antibody, clone BB1E2 recognizes the human gamma-interferon receptor, also known as CD119. CD119 is expressed by monocytes, and very weakly by resting peripheral blood lymphocytes. Mouse anti Human CD119 antibody, clone BB1E2 has been described as useful for Western Blotting where it stains a single protein band is stained corresponding to a MW of ~43kDa, which is equal to the MW for the glycosylated extracellular domain of the human interferon-gamma receptor (fused to c-myc), and a MW of 27kDa corresponding to the non-glycosylated domain (fused to c-myc). Mouse anti Human CD119 antibody, clone BB1E2 does not neutralize biological activity of interferon gamma.

Immunohistology Frozen*, ELISA (EIA), Flow cytometry (FC/FACS), Western Blot (WB)

Flow Cytometry: Use 1ug to label 106 cells in 100ul.
Immunohistology - Frozen: Minimum Dilution: 1ug/ml; Maximum Dilution: 10ug/ml; Application Note: The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. MyBioSource recommends the use of acetone fixation for frozen sections.
ELISA: Maximum Dilution: 1ug/ml
Flow Cytometry: Minimum Dilution: 1ug/ml; Maximum Dilution: 10ug/ml
Western Blotting: Maximum Dilution: 1ug/ml

Staining of human peripheral blood monocytes with Mouse anti Human CD119:FITC (MBS210699)

Staining of human peripheral blood monocytes with Mouse anti Human CD119:Alexa Fluor 488 (MBS212159A488)

21,542 Da

interferon gamma receptor 1

interferon gamma receptor 1; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antiviral protein, type 2; immune interferon receptor 1; interferon-gamma receptor alpha chain

Interferon gamma receptor 1

IFN-gamma receptor 1; IFN-gamma-R1??[Similar Products]

INGR1_HUMAN

This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]

IFNGR1: Receptor for interferon gamma. Two receptors bind one interferon gamma dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type II cytokine receptor family.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: integral to plasma membrane; endoplasmic reticulum; dendrite; postsynaptic density; integral to membrane; plasma membrane; vesicle

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; interferon-gamma receptor activity; cytokine binding

Biological Process: response to virus; cytokine and chemokine mediated signaling pathway; signal transduction

Disease: Helicobacter Pylori Infection, Susceptibility To; Immunodeficiency 27b; Immunodeficiency 27a; Mycobacterium Tuberculosis, Susceptibility To; Hepatitis B Virus, Susceptibility To

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