Full Product Name
AF/LE Purified Anti-Mouse CD119 Monoclonal Antibody
Product Synonym Names
Interferon gamma receptor 1; Ifngr1; IFN-gamma-R1; IFN-gamma-R-alpha; CD119
Product Gene Name
anti-CD119 antibody
[Similar Products]
Product Synonym Gene Name
Mouse CD119[Similar Products]
Matching Pairs
Antibody: CD119 Clone #GR-20 (MBS2558795)
Isotype Control: IgG2a, kappa Clone #2A3 (MBS2557851)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P15261
Form/Format
0.2 mum filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives.
Concentration
0.5 mg/mL (lot specific)
Conjugation
None (Purified antibody, Low endotoxin/Azide Free)
Endotoxin
Endotoxin level is < 2 EU/mg (< 0.002EU/mug) as Determined by LAL gel clotting assay.
Preparation and Storage
Store at 2-8 degree C. Do not freeze.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CD119 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD119 antibody
CDw119 is a 90 kD immunoglobulin superfamily member, also known as IFN-gammaRalpha chain. It is a class II cytokine receptor family member that serves as a IFN-gamma-binding chain associated with the IFN-gamma beta chain also known as AF-1. In addition to ligand binding, CDw119 participates in ligand trafficking. CDw119 is expressed on T and B cells, NK cells, fibroblasts, endothelial, and epithelial cells. Binding of IFN-gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-gamma initiates and regulates a variety of immune responses.
Applications Tested/Suitable for anti-CD119 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD119 antibody
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is <= 2.0 ug per 106 cells in 100 ul volume or 100 ul of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
NCBI/Uniprot data below describe general gene information for CD119. It may not necessarily be applicable to this product.
NCBI Accession #
NP_034641.1
[Other Products]
NCBI GenBank Nucleotide #
NP_034641.1
[Other Products]
UniProt Primary Accession #
P15261
[Other Products]
UniProt Related Accession #
P15261[Other Products]
NCBI Official Full Name
interferon gamma receptor 1
NCBI Official Synonym Full Names
interferon gamma receptor 1
NCBI Official Symbol
Ifngr1??[Similar Products]
NCBI Official Synonym Symbols
Ifgr; CD119; Ifngr; Nktar; IFN-gammaR
??[Similar Products]
NCBI Protein Information
interferon gamma receptor 1
UniProt Protein Name
Interferon gamma receptor 1
UniProt Gene Name
Ifngr1??[Similar Products]
UniProt Synonym Gene Names
Ifngr; IFN-gamma receptor 1??[Similar Products]
UniProt Entry Name
INGR1_MOUSE
UniProt Comments for CD119
Function: Receptor for interferon gamma. Two receptors bind one interferon gamma dimer.
Subcellular location: Membrane; Single-pass type I membrane protein.
Post-translational modification: Phosphorylated at Ser/Thr residues.
Sequence similarities: Belongs to the type II cytokine receptor family.Contains 2 fibronectin type-III domains.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Sequence caution: The sequence AAA37895.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
Research Articles on CD119
1. An Hematopoietic Stem Cell-based gene therapy approach for IFNgammaR1 deficiency, which protects mice from severe mycobacterial infections, thereby laying the foundation for a new therapeutic intervention in corresponding human patients.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
