CD1E; T-cell surface glycoprotein CD1e, membrane-associated; hCD1e; R2G1; CD1e

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

CD1E Polyclonal Antibody detects endogenous levels of CD1E protein.

>=90% by SDS-PAGE
Affinity purified by Protein A.

Lyophilized or Liquid

1 mg/mL (lot specific)

Upon delivery aliquot and store at -20 degree C for one year. Avoid repeated freeze/thaw cycles.
The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20 degree C.
When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-8 degree C.

Small volumes of anti-CD1E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA)

WB: 1:500-2000
IHC-p: 1:100-300
ELISA: 1:20000

42 kDa

CD1e molecule

T-cell surface glycoprotein CD1e, membrane-associated

T-cell surface glycoprotein CD1e, membrane-associated

hCD1e; sCD1e??[Similar Products]

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.

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