Product Name
Filaggrin (FLG), Polyclonal Antibody
Popular Item
Full Product Name
Anti-Filaggrin Antibody
Product Synonym Names
Filaggrin
Product Gene Name
anti-FLG antibody
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Antibody/Peptide Pairs
Filaggrin peptide (MBS8243402) is used for blocking the activity of Filaggrin antibody (MBS8243034)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P20930
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of Filaggrin protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Filaggrin. The exact sequence is proprietary.
Preparation and Storage
Shipping: Blue Ice.
Upon delivery aliquot and store at - 20°C for one year.
Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-FLG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FLG antibody
Rabbit polyclonal antibody to Filaggrin
Applications Tested/Suitable for anti-FLG antibody
Western Blot (WB)
Application Notes for anti-FLG antibody
Western Blot: (1/500 - 1/1000)
Western Blot (WB) of anti-FLG antibody
Western blot analysis of Filaggrin expression in HeLa (A), NS-1 (B), PC12 (C) whole cell lysates.
NCBI/Uniprot data below describe general gene information for FLG. It may not necessarily be applicable to this product.
NCBI Accession #
P20930.3
[Other Products]
UniProt Primary Accession #
P20930
[Other Products]
UniProt Secondary Accession #
Q01720; Q5T583; Q9UC71[Other Products]
UniProt Related Accession #
P20930[Other Products]
NCBI Official Full Name
Filaggrin
NCBI Official Synonym Full Names
filaggrin
NCBI Official Symbol
FLG??[Similar Products]
NCBI Official Synonym Symbols
ATOD2
??[Similar Products]
NCBI Protein Information
filaggrin
UniProt Protein Name
Filaggrin
UniProt Gene Name
FLG??[Similar Products]
UniProt Entry Name
FILA_HUMAN
NCBI Summary for FLG
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
UniProt Comments for FLG
FLG: Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. Defects in FLG are the cause of ichthyosis vulgaris (VI); also known as ichthyosis simplex. Ichthyosis vulgaris is the most common form of ichthyosis inherited as an autosomal dominant trait. It is characterized by palmar hyperlinearity, keratosis pilaris and a fine scale that is most prominent over the lower abdomen, arms, and legs. Ichthyosis vulgaris is characterized histologically by absent or reduced keratohyalin granules in the epidermis and mild hyperkeratosis. The disease can be associated with frequent asthma, eczema or hay fever. Defects in FLG are a cause of susceptibility to dermatitis atopic type 2 (ATOD2). Atopic dermatitis is a complex, inflammatory disease with multiple alleles at several loci thought to be involved in the pathogenesis. It commonly begins in infancy or early childhood and is characterized by a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry skin, and IgE- mediated sensitization to food and environmental allergens. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. Belongs to the S100-fused protein family.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: intermediate filament; intracellular membrane-bound organelle; nucleus
Molecular Function: calcium ion binding; protein binding; structural molecule activity
Biological Process: keratinocyte differentiation; multicellular organismal development
Disease: Dermatitis, Atopic, 2; Ichthyosis Vulgaris
Research Articles on FLG
1. Filaggrin polymorphism Pro478Ser Is associated with increased disease severity and staphylococcus aureus colonization in atopic dermatitis patients.
Precautions
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Disclaimer
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