Product Name
ICE, Peptide
Full Product Name
ICE (Caspase-1) Suc-Tyr-Val-Ala-Asp-AMC
Product Gene Name
Ice peptide
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 3R; NT_033777.2 (25625375..25627307). Location: 99C1-99C1
3D Structure
ModBase 3D Structure for O01382
Purity/Purification
Highly Purified
~95%. Purified by HPLC.
Form/Format
Supplied as a lyophilized powder.
Sequence (linear)
Suc-Tyr-Val-Ala-Asp-AMC
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of Ice peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Ice peptide
Molecular Biology; MB-Apoptosis, Caspase
NCBI/Uniprot data below describe general gene information for Ice. It may not necessarily be applicable to this product.
NCBI Accession #
NP_524551.2
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NCBI GenBank Nucleotide #
NM_079827.2
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UniProt Primary Accession #
O01382
[Other Products]
UniProt Secondary Accession #
Q9VAH1[Other Products]
UniProt Related Accession #
O01382[Other Products]
Molecular Weight
37,363 Da[Similar Products]
NCBI Official Full Name
Ice
NCBI Official Symbol
Ice??[Similar Products]
NCBI Official Synonym Symbols
caspase 3; CG7788; crice; DmelCG7788; drice; drIce; drICE; Drice; DrIce; DrICE; DRICE; ice; ICE
??[Similar Products]
NCBI Protein Information
CG7788 gene product from transcript CG7788-RA; CG7788-PA; Ice; Ice-PA; caspase-3; drice; interleukin-1beta-converting enzyme
UniProt Protein Name
Caspase
UniProt Synonym Protein Names
drICE
Protein Family
ICEBs1 integrase
UniProt Gene Name
Ice??[Similar Products]
UniProt Entry Name
ICE_DROME
UniProt Comments for Ice
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Acts downstream of rpr. Cleaves baculovirus p35 and lamin DmO in vitro.
Subunit structure: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 21 kDa (p21) and a 12 kDa (p12) subunit. Inactive pro-form can homodimerize. Nc and Ice can form a stable complex. Ref.5
Developmental stage: Expressed at all stages where apoptosis occurs.
Sequence similarities: Belongs to the peptidase C14A family.
Research Articles on Ice
1. The cleaved DIAP1 binds drICE, inhibits its protease activity, and also targets drICE for ubiquitylation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
