Product Name
IFN-gamma R alpha (IFNGR1), Polyclonal Antibody
Full Product Name
IFN-gamma Ralpha (phospho Tyr457) Polyclonal Antibody
Product Gene Name
anti-IFNGR1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P15260
Other Notes
Small volumes of anti-IFNGR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for IFNGR1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000407.1
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NCBI GenBank Nucleotide #
NM_000416.2
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UniProt Primary Accession #
P15260
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UniProt Secondary Accession #
Q53Y96; B4DFT7; E1P587[Other Products]
UniProt Related Accession #
P15260[Other Products]
Molecular Weight
21,542 Da[Similar Products]
NCBI Official Full Name
interferon gamma receptor 1
NCBI Official Synonym Full Names
interferon gamma receptor 1
NCBI Official Symbol
IFNGR1??[Similar Products]
NCBI Official Synonym Symbols
CD119; IFNGR; IMD27A; IMD27B
??[Similar Products]
NCBI Protein Information
interferon gamma receptor 1
UniProt Protein Name
Interferon gamma receptor 1
UniProt Synonym Protein Names
CDw119; Interferon gamma receptor alpha-chain
Protein Family
Interferon gamma receptor
UniProt Gene Name
IFNGR1??[Similar Products]
UniProt Synonym Gene Names
IFN-gamma-R-alpha??[Similar Products]
NCBI Summary for IFNGR1
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]
UniProt Comments for IFNGR1
Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114). Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents (PubMed:20015550).
Research Articles on IFNGR1
1. All known mutations, as well as 287 other variations, have been deposited in the online IFNGR1 variation database . In this article, we review the function of IFN-gammaR1 and molecular genetics of human IFNGR1.
Precautions
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Disclaimer
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