TTF1 Mouse mAb

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG

Mouse

Store at -20 degree C. Stable for one year from the date of shipment.

Small volumes of anti-NKX2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.

Nucleus; Pathlogic Biomarker

Western Blot (WB)

WB: 1:1000-1:5000

Lane 1 : TTF-1 Mouse mAb at 1/1000 dilution

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Mouse IgG-HRP, 5% milk conjugated at 1/10000 dilution

Predicted band size : 38 KDa
Observed band size : 38 KDa
Blocking/Dilution buffer : 1x TBST.

Predicted MW: 38kDa

NK2 homeobox 1

homeobox protein Nkx-2.1

Homeobox protein Nkx-2.1

TTF-1; T/EBP??[Similar Products]

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]

Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 ().

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