Nucleoporin GLE1; hGLE1; GLE1-like protein; GLE1; GLE1L

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>95%,Protein G purified

Liquid

Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-GLE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).

ELISA (EIA)

Western Blot
Positive WB detected in: HepG2 whole cell lysate,A549 whole cell lysate,MCF-7 whole cell lysate
All lanes: GLE1 antibody at 2.8ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 80,76 KDa
Observed band size: 80 KDa

Immunocytochemistry analysis of human melanoma cancer using MBS7000464 at dilution of 1:100

Immunocytochemistry analysis of human breast cancer using MBS7000464 at dilution of 1:100

Immunofluorescent analysis of MCF-7 cells using MBS7000464 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

75,407 Da

Nucleoporin GLE1

GLE1L; hGLE1??[Similar Products]

GLE1_HUMAN

GLE1: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). Defects in GLE1 are the cause of lethal congenital contracture syndrome type 1 (LCCS1); also known as multiple contracture syndrome type Finnish. LCCS is an autosomal recessive disorder characterized by early fetal hydrops and akinesia, micrognatia, pulmonary hypoplasia, pterygia, multiple joint contractures, specific neuropathology with degeneration of anterior horn neurons and extreme skeletal muscle atrophy. LCCS1 leads to prenatal death. Defects in GLE1 are the cause of lethal arthrogryposis with anterior horn cell disease (LAAHD). LAAHD is characterized by fetal akinesia, arthrogryposis and motor neuron loss. LAADH fetus often survive delivery, but die early as a result of respiratory failure. Neuropathological findings resemble those of LCCS1, but are less severe. Belongs to the GLE1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear export; Karyopherin

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: cytoplasm; extracellular space; membrane; nuclear pore; plasma membrane

Molecular Function: identical protein binding; protein binding

Biological Process: mRNA export from nucleus; poly(A)+ mRNA export from nucleus; protein transport

Disease: Lethal Arthrogryposis With Anterior Horn Cell Disease; Lethal Congenital Contracture Syndrome 1

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