Product Name
GLE1, cDNA Clone
Full Product Name
GLE1 cDNA Clone
Product Gene Name
GLE1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgccgtctg agggtcgctg ctgggagacc ttgaaggccc tacgcagttc cgacaaaggt cgcctttgct actaccgcga ctggctgctg cggcgcgagg atgttttaga agaatgtatg tctcttccca agctatcttc ttattctgga tgggtggtag agcacgtcct accccatatg caggagaacc aacctctgtc tgagacttcg ccatcctcta cgtcagcttc agccctagat caaccctcat ttgttcccaa atctcctgac gcaagctctg ccttttcccc agcctcccct gcaacaccaa atggaaccaa gggcaaagat gagtcccagc acacagaatc tatggtactt cagtcctcac gggggatcaa agtggaagac tgcgtccgaa tgtacgaact ggtacacaga atgaaaggaa cagagggcct gaggctatgg caggaggagc aggagaggaa ggtgcaagcc ctctcggaga tggcatctga acaactgaag cggtttgatg aatggaagga actgaagcag cataaagaat tccaggactt gcgggaagta atggagaaga gctccagaga agccttggga caccaagaga agctaaaagc tgagcaccgt cacagagcaa agattctcaa cctgaagctg cgggaagcag agcagcagcg cgtgaagcaa gcagaacagg agcggcttcg gaaggaagaa ggccagatcc gcctgcgggc cctctatgct ctgcaggagg agatgctgca gctcagccag cagctggatg cctctgagca gcacaaagcc ctgcttaagg tcgacctggc tgccttccag acccgaggca accagctgtg cagcctcatc tcagggatca tccgggcctc ttcagagagc agctatccca cagcagagag tcaagctgag gctgagcgag ctctgcggga aatgcgggac ctcctgatga acttggggca ggagatcacc agagcctgcg aagacaagag gaggcaggat gaagaagagg cccaggtaaa gctgcaagag gcacagatgc agcagggacc agaggcccac aaagagcccc cagctcccag ccagggccca ggagggaaac agaatgaaga cctccaggtg aaggtacaag acattacaat gcagtggtac cagcagctgc aggatgcttc catgcagtgt gtgttgacct ttgagggcct gaccaacagc aaggacagtc aggccaaaaa gataaagatg gacctccaga aggctgctac catcccagtg agccaaatct ctaccattgc aggctcaaaa ctgaaggaga tctttgacaa gatccacagc ctgctctctg gaaaacctgt tcaatctggt gggcgctctg tgtctgtcac acttaaccca caggggctgg actttgttca atacaaactg gcagagaaat ttgtgaaaca aggcgaggag gaagtggcct ctcaccatga agcagcattc cccattgcag ttgtggcatc cgggatctgg gagctccacc ccagagtggg ggacctcatt cttgctcatc tacataagaa gtgtccttac tctgttcctt tctatcccac tttcaaggag ggaatggctt tggaagacta tcagaggatg cttggttacc aagtaaagga ttccaaagtg gagcagcaag acaactttct aaaacgcatg tcagggatga tccgtctcta cgctgctatc atccagctcc ggtggccata tggaaaccaa caggagattc accctcatgg cttaaatcat ggatggcgct ggttggcaca gatcttaaac atggagccct tgtcagatgt gacagccacc ctcctctttg acttcctgga ggtgtgtggg aatgccctca tgaagcaata ccaggttcag ttctggaaga tgctaattct catcaaagag gactactttc ccagaattga agctatcaca agctcaggac agatgggctc cttcatacgc ctcaagcagt tcttggagaa atgtttgcaa cacaaggaca ttcctgtccc caagggcttt ctgacttcct ccttctggcg ctcctga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of GLE1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for GLE1. It may not necessarily be applicable to this product.
NCBI Accession #
BC030012
[Other Products]
UniProt Secondary Accession #
O75458; Q53GT9; Q5VVU1; Q8NCP6; Q9UFL6[Other Products]
UniProt Related Accession #
Q53GS7[Other Products]
Molecular Weight
75,407 Da
NCBI Official Full Name
Homo sapiens GLE1 RNA export mediator homolog (yeast), mRNA
NCBI Official Synonym Full Names
GLE1, RNA export mediator
NCBI Official Symbol
GLE1??[Similar Products]
NCBI Official Synonym Symbols
LCCS; GLE1L; LCCS1; hGLE1
??[Similar Products]
NCBI Protein Information
nucleoporin GLE1
UniProt Protein Name
Nucleoporin GLE1
UniProt Synonym Protein Names
GLE1-like protein
UniProt Gene Name
GLE1??[Similar Products]
UniProt Synonym Gene Names
GLE1L; hGLE1??[Similar Products]
UniProt Entry Name
GLE1_HUMAN
NCBI Summary for GLE1
This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for GLE1
GLE1: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). Defects in GLE1 are the cause of lethal congenital contracture syndrome type 1 (LCCS1); also known as multiple contracture syndrome type Finnish. LCCS is an autosomal recessive disorder characterized by early fetal hydrops and akinesia, micrognatia, pulmonary hypoplasia, pterygia, multiple joint contractures, specific neuropathology with degeneration of anterior horn neurons and extreme skeletal muscle atrophy. LCCS1 leads to prenatal death. Defects in GLE1 are the cause of lethal arthrogryposis with anterior horn cell disease (LAAHD). LAAHD is characterized by fetal akinesia, arthrogryposis and motor neuron loss. LAADH fetus often survive delivery, but die early as a result of respiratory failure. Neuropathological findings resemble those of LCCS1, but are less severe. Belongs to the GLE1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Karyopherin; Nuclear export
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: cytoplasm; extracellular space; membrane; nuclear pore; plasma membrane
Molecular Function: identical protein binding; inositol hexakisphosphate binding; phospholipid binding; protein binding; translation initiation factor binding
Biological Process: mRNA export from nucleus; regulation of translational initiation; regulation of translational termination
Disease: Lethal Arthrogryposis With Anterior Horn Cell Disease; Lethal Congenital Contracture Syndrome 1
Research Articles on GLE1
1. Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6.
Precautions
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Disclaimer
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