Product Name
IFN-gamma Receptor-1, Monoclonal Antibody
Full Product Name
Rat Anti-Mouse IFN-gamma Receptor-1
Product Synonym Names
Anti-mouse Interferon-gamma R1 [INFgammaR1] (#7K23)
Product Gene Name
anti-IFN-gamma Receptor-1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 10; NC_000076.6 (19591958..19610225). Location: 10 A3; 10 8.49 cM
3D Structure
ModBase 3D Structure for P15261
Specificity
This antibody detects mouse INFgammaR1 in Western blotting.
Purity/Purification
Protein A/G affinity chromatography
Form/Format
The IgG fraction of culture supernatant was purified by Protein A/G affinity chromatography and lyophilized from a 0.2 um filtered solution in phosphate-buffered saline (PBS). Lyophilized samples are stable for 2 years from date of receipt when stored at
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-IFN-gamma Receptor-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IFN-gamma Receptor-1 antibody
The high-affinity IFN-gamma receptor complex is made up of two type I transmembrane proteins, IFN-gamma R1 (IFN-gamma R alpha) and IFN-gamma R2 (IFN-gamma R beta). Both proteins are members of the type II cytokine receptor family. IFN-gamma R1 is the ligand-binding subunit that is necessary and sufficient for IFN-gamma binding and receptor internalization. IFN-gamma R2 is required for IFN-gamma signaling, but does not bind IFN-gamma by itself.
Applications Tested/Suitable for anti-IFN-gamma Receptor-1 antibody
Western Blot (WB)
Application Notes for anti-IFN-gamma Receptor-1 antibody
1. Western blot: Yes (1:500-1000)
NCBI/Uniprot data below describe general gene information for IFN-gamma Receptor-1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_034641.1
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NCBI GenBank Nucleotide #
NM_010511.2
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UniProt Primary Accession #
P15261
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UniProt Secondary Accession #
Q91Y85[Other Products]
UniProt Related Accession #
P15261[Other Products]
Molecular Weight
52,343 Da
NCBI Official Full Name
interferon gamma receptor 1
NCBI Official Synonym Full Names
interferon gamma receptor 1
NCBI Official Symbol
Ifngr1??[Similar Products]
NCBI Official Synonym Symbols
Ifgr; CD119; Ifngr; Nktar; IFN-gammaR
??[Similar Products]
NCBI Protein Information
interferon gamma receptor 1; IFN-gamma-R1; INF-g receptor; IFN-gamma receptor 1; interferon-gamma receptor 1
UniProt Protein Name
Interferon gamma receptor 1
UniProt Gene Name
Ifngr1??[Similar Products]
UniProt Synonym Gene Names
Ifngr; IFN-gamma receptor 1??[Similar Products]
UniProt Entry Name
INGR1_MOUSE
UniProt Comments for IFN-gamma Receptor-1
Function: Receptor for interferon gamma. Two receptors bind one interferon gamma dimer.
Subcellular location: Membrane; Single-pass type I membrane protein.
Post-translational modification: Phosphorylated at Ser/Thr residues.
Sequence similarities: Belongs to the type II cytokine receptor family.Contains 2 fibronectin type-III domains.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Sequence caution: The sequence AAA37895.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
Research Articles on IFN-gamma Receptor-1
1. These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3/Nab1 complex that silences transcription from the ifngr1 promoter.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
