Product Name
IFNgR1, Polyclonal Antibody
Full Product Name
Human IFNgR1 Affinity Purified Polyclonal
Product Synonym Names
RAA05169; polyclonal; IFNgR1
Product Gene Name
anti-IFNgR1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 6; NC_000006.11 (137518621..137540981, complement). Location: 6q23.3
3D Structure
ModBase 3D Structure for P15260
Preparation and Storage
This antibody can be stored in working aliquots at 2C - 8C for one month without detectable loss of activity. The antibody is stable for at least 1 year from date of receipt at -20C.
Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-IFNgR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-IFNgR1 antibody
Antigen affinity polyclonals
Application Notes for anti-IFNgR1 antibody
Western Blot Concentration: 0.1-0.2 ug/ml
Western Blot Limit: 0.5ng/lane
ELISA Concentration: 0.5-1.0 ug/ml
ELISA Limit: 2 pg/well
NCBI/Uniprot data below describe general gene information for IFNgR1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000407.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000416.2
[Other Products]
UniProt Primary Accession #
P15260
[Other Products]
UniProt Secondary Accession #
Q53Y96; E1P587[Other Products]
UniProt Related Accession #
P15260[Other Products]
Molecular Weight
54,405 Da
NCBI Official Full Name
interferon gamma receptor 1
NCBI Official Synonym Full Names
interferon gamma receptor 1
NCBI Official Symbol
IFNGR1??[Similar Products]
NCBI Official Synonym Symbols
CD119; IFNGR
??[Similar Products]
NCBI Protein Information
interferon gamma receptor 1; CDw119; AVP, type 2; IFN-gamma-R1; CD119 antigen; IFN-gamma receptor 1; antiviral protein, type 2; immune interferon receptor 1; interferon-gamma receptor alpha chain
UniProt Protein Name
Interferon gamma receptor 1
UniProt Synonym Protein Names
CDw119
Protein Family
Interferon gamma receptor
UniProt Gene Name
IFNGR1??[Similar Products]
UniProt Synonym Gene Names
IFN-gamma receptor 1??[Similar Products]
UniProt Entry Name
INGR1_HUMAN
NCBI Summary for IFNgR1
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]
UniProt Comments for IFNgR1
IFNGR1: Receptor for interferon gamma. Two receptors bind one interferon gamma dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type II cytokine receptor family.
Protein type: Receptor, cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6q23.3
Cellular Component: endoplasmic reticulum; integral to plasma membrane; postsynaptic density; dendrite; plasma membrane; integral to membrane; vesicle
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; interferon-gamma receptor activity; cytokine binding
Biological Process: response to virus; cytokine and chemokine mediated signaling pathway; signal transduction
Disease: Helicobacter Pylori Infection, Susceptibility To; Immunodeficiency 27b; Immunodeficiency 27a; Mycobacterium Tuberculosis, Susceptibility To; Hepatitis B Virus, Susceptibility To
Research Articles on IFNgR1
1. An association study of functional polymorphic genes .... IFNGR-1, ...... with disease progression, aspartate aminotransferase, alanine aminotransferase, and viral load in chronic hepatitis B and C.
Precautions
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Disclaimer
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