Mouse Nucleoporin GLE1 (GLE1) ELISA kit; GLE1L; LCCS; LCCS1; hGLE1; GLE1 RNA export mediator homolog; GLE1 RNA export mediator-like; GLE1-like; RNA export mediator; GLE1 RNA export mediator homolog (yeast)

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of GLE1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9330364 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the GLE1 RNA export mediator homolog (yeast) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GLE1. The ELISA analytical biochemical technique of the MBS9330364 kit is based on GLE1 antibody-GLE1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GLE1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GLE1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

79,574 Da

GLE1 RNA export mediator (yeast)

nucleoporin GLE1; GLE1-like protein

Nucleoporin GLE1

Gle1l??[Similar Products]

GLE1_MOUSE

GLE1: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC). Defects in GLE1 are the cause of lethal congenital contracture syndrome type 1 (LCCS1); also known as multiple contracture syndrome type Finnish. LCCS is an autosomal recessive disorder characterized by early fetal hydrops and akinesia, micrognatia, pulmonary hypoplasia, pterygia, multiple joint contractures, specific neuropathology with degeneration of anterior horn neurons and extreme skeletal muscle atrophy. LCCS1 leads to prenatal death. Defects in GLE1 are the cause of lethal arthrogryposis with anterior horn cell disease (LAAHD). LAAHD is characterized by fetal akinesia, arthrogryposis and motor neuron loss. LAADH fetus often survive delivery, but die early as a result of respiratory failure. Neuropathological findings resemble those of LCCS1, but are less severe. Belongs to the GLE1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Karyopherin; Nuclear export

Cellular Component: extracellular space; membrane; cytoplasm; plasma membrane; nuclear pore; nucleus

Molecular Function: identical protein binding

Biological Process: protein transport; poly(A)+ mRNA export from nucleus; mRNA transport; transport

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