Homeobox protein Hox-D4; Homeobox protein HHOC13; Homeobox protein Hox-4B; Homeobox protein Hox-51; HOXD4; HOX4B

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This HOXD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the C-terminal region of human HOXD4.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-HOXD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene belongs to the homeobox family of genes. The
homeobox genes encode a highly conserved family of transcription
factors that play an important role in morphogenesis in all
multicellular organisms. Mammals possess four similar homeobox gene
clusters, HOXA, HOXB, HOXC and HOXD, located on different
chromosomes, consisting of 9 to 11 genes arranged in tandem. This
gene is one of several homeobox HOXD genes located at 2q31-2q37
chromosome regions. Deletions that removed the entire HOXD gene
cluster or 5' end of this cluster have been associated with severe
limb and genital abnormalities. The protein encoded by this gene
may play a role in determining positional values in developing limb
buds. Alternatively spliced variants have been described but their
full length nature has not been determined.

Western Blot (WB), ELISA (EIA)

WB~~1:1000

HOXD4 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the HOXD4 antibody detected the HOXD4 protein (arrow).

27885

homeobox D4

homeobox protein Hox-D4

Homeobox protein Hox-D4

HOX4B??[Similar Products]

HXD4_HUMAN

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

HOXD4: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Antp homeobox family. Deformed subfamily.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: nucleus

Molecular Function: sequence-specific DNA binding; transcription factor activity

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development

Zhang, H., et al. Acta Pharmacol. Sin. 31(8):977-983(2010)
Ester, A.R., et al. Am. J. Med. Genet. A 149A (12), 2745-2752 (2009) :
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Tan, Y., et al. BMC Mol. Biol. 10, 12 (2009) :
van Scherpenzeel Thim, V., et al. Hum. Mutat. 25(4):384-395(2005)

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