Muscle, skeletal receptor tyrosine-protein kinase; Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor; Musk; Nsk2; 2.7.10.1

For Research Use Only. Not for use in diagnostic procedures.

For long term storage, please store the entire kit at -20 degree C.

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Small volumes of Musk elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2882781 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Muscle, skeletal receptor tyrosine-protein kinase (Musk) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Musk. The ELISA analytical biochemical technique of the MBS2882781 kit is based on Musk antibody-Musk antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Musk antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Musk. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

98,081 Da

muscle, skeletal, receptor tyrosine kinase

muscle, skeletal receptor tyrosine-protein kinase

Muscle, skeletal receptor tyrosine-protein kinase

Nsk2; MuSK; Muscle-specific kinase receptor??[Similar Products]

MUSK_MOUSE

This gene encodes a member of the protein tyrosine kinase family. The encoded protein is a type 1 receptor-like protein located in muscle membrane that is activated by the heparan sulfate proteoglycan agrin released by nerve cells. The encoded protein activates signaling cascades responsible for multiple aspects of motor neuron and muscle development, including organization of the postsynaptic membrane, synaptic gene transcription, patterning of skeletal muscle, anchoring of acetylcholinesterase, and guidance of motor axons. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

MUSK: a receptor tyrosine kinase that is essential for the establishment and maintenance of the neuromuscular junction (NMJ). Its activation by agrin, a neuronally derived heparan-sulfate proteoglycan, and the agrin receptor (LRP4), leads to clustering of acetylcholine receptors on the postsynaptic side of the NMJ. Its activation by agrin requires Dok7, which interacts with the cytoplasmic portion of MuSK and activates its tyrosine kinase activity.

Protein type: Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; Kinase, protein; EC 2.7.10.1; TK group; Musk family

Cellular Component: cell junction; cell projection; external side of plasma membrane; integral to membrane; integral to plasma membrane; membrane; neuromuscular junction; plasma membrane; postsynaptic membrane; receptor complex; synapse

Molecular Function: ATP binding; kinase activity; metal ion binding; nucleotide binding; PDZ domain binding; protein binding; protein kinase activity; protein kinase binding; protein-tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: cell differentiation; memory; multicellular organismal development; neuromuscular junction development; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of neuron apoptosis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of synaptic growth at neuromuscular junction; positive regulation of synaptic transmission, cholinergic; protein amino acid autophosphorylation; protein amino acid phosphorylation; receptor clustering; regulation of synaptic growth at neuromuscular junction; regulation of transcription, DNA-dependent; response to electrical stimulus

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