Full Product Name
NKX2-1 Antibody
Product Gene Name
anti-NKX2-1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P43699
Species Reactivity
Human, Mouse, Rat
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-NKX2-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-NKX2-1 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for NKX2-1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001073136.1
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NCBI GenBank Nucleotide #
NM_001079668.2
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UniProt Primary Accession #
P43699
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UniProt Secondary Accession #
O14954; O14955; Q7KZF6; Q9BRJ8; D3DSA3[Other Products]
UniProt Related Accession #
P43699[Other Products]
Molecular Weight
41,737 Da
NCBI Official Full Name
homeobox protein Nkx-2.1 isoform 1
NCBI Official Synonym Full Names
NK2 homeobox 1
NCBI Official Symbol
NKX2-1??[Similar Products]
NCBI Official Synonym Symbols
BCH; BHC; NK-2; TEBP; TTF1; NKX2A; NMTC1; T/EBP; TITF1; TTF-1; NKX2.1
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NCBI Protein Information
homeobox protein Nkx-2.1
UniProt Protein Name
Homeobox protein Nkx-2.1
UniProt Synonym Protein Names
Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1; Thyroid-specific enhancer-binding protein; T/EBP
Protein Family
Homeobox protein
UniProt Gene Name
NKX2-1??[Similar Products]
UniProt Synonym Gene Names
TTF-1; T/EBP??[Similar Products]
NCBI Summary for NKX2-1
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]
UniProt Comments for NKX2-1
NKX2-1: a homeobox transcription factor expressed in thyroid, lung, and parts of the brain. Essential for the branching morphogenesis of the lung. Binds and activates the promoters of CEACAM6, thyroid-specific genes, ROR1, LAMP3, VEGF, etc. Its transcription is responsive to SMAD2 signaling after endodermal differentiation is induced in embryonic stem cell. Defects in NKX2-1 are associated with neurological, thyroid, and respiratory problems. Frequent amplified in human lung cancer cell lines and tumors. Amplified in 15% of non-small cell lung cancers (NSCLC), and appears to drive cancer cell proliferation and survival. EGFR may be a downstream effector of NKX2-1 when amplified in NSCLC. May operate as a lineage-specific oncogene in lung adenocarcinoma. Belongs to the NK-2 homeobox family. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1. Belongs to the NK-2 homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 14q13.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA binding; enzyme binding; protein binding; transcription factor activity
Biological Process: brain development; forebrain development; globus pallidus development; lung development; negative regulation of cell migration; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of circadian rhythm; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to hormone stimulus; thyroid gland development
Disease: Chorea, Benign Hereditary; Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction; Thyroid Carcinoma, Papillary
Research Articles on NKX2-1
1. These findings describe recurrent NKX2-1 mutations in invasive mucinous adenocarcinomas of the lung and support NKX2-1 as a lineage-specific tumor suppressor gene in lung carcinogenesis.
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