For Research Use Only. Not for use in diagnostic procedures.

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Small volumes of VANGL2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2888250 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Vang-like protein 2 (VANGL2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing VANGL2. The ELISA analytical biochemical technique of the MBS2888250 kit is based on VANGL2 antibody-VANGL2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect VANGL2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, VANGL2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

59,714 Da

VANGL planar cell polarity protein 2

vang-like protein 2

Vang-like protein 2

KIAA1215; STB1??[Similar Products]

The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]

VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.

Protein type: Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: apical plasma membrane; basolateral plasma membrane; COPII-coated ER to Golgi transport vesicle; integral component of membrane; intercellular junction; lateral plasma membrane; plasma membrane; stress fiber

Molecular Function: protein binding

Biological Process: anterior/posterior pattern specification; apical protein localization; cochlea morphogenesis; convergent extension involved in axis elongation; convergent extension involved in neural plate elongation; digestive tract morphogenesis; dopaminergic neuron axon guidance; establishment of body hair orientation; establishment of planar polarity; establishment of planar polarity involved in neural tube closure; establishment or maintenance of epithelial cell apical/basal polarity; glomerulus development; hair follicle development; heart looping; heparan sulfate proteoglycan biosynthetic process; inner ear receptor stereocilium organization and biogenesis; membranous septum morphogenesis; muscular septum morphogenesis; neural tube closure; non-motile cilium assembly; planar cell polarity pathway involved in axis elongation; planar cell polarity pathway involved in axon guidance; planar cell polarity pathway involved in neural tube closure; positive regulation of JUN kinase activity; regulation of actin cytoskeleton organization; regulation of Wnt receptor signaling pathway; Rho protein signal transduction; serotonergic neuron axon guidance; somatic stem cell division; somatic stem cell maintenance; wound healing

Disease: Neural Tube Defects

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