Anti -AT Rich Interactive Domain 4A (ARID4A, RBP1-Like)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 14; NC_000014.8 (58765222..58840451). Location: 14q23.1

Monoclonal

IgG1

8C25

Mouse

Recognizes human AT Rich Interactive Domain 4A.

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-ARID4A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

AT Rich Interactive Domain 4A (ARID4A) is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity.

Antibodies; Abs to Binding Proteins

Western Blot (WB), Gel Shift Assay (GS/EMSA)

Suitable for use in Dot Blot and Western Blot.
Dilution: Western Blot: 1:1000-1:2000

142,752 Da[Similar Products]

AT rich interactive domain 4A (RBP1-like)

AT-rich interactive domain-containing protein 4A; OTTHUMP00000179023; OTTHUMP00000179024; retinoblastoma binding protein 1; retinoblastoma-binding protein 1; ARID domain-containing protein 4A

AT-rich interactive domain-containing protein 4A

RBBP1; RBP1??[Similar Products]

ARI4A_HUMAN

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq]

RbBP1: Interacts with the viral protein-binding domain of the retinoblastoma protein. Interacts with BRMS1. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, BRMS1, HDAC1 and HDAC2. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 14q23.1

Cellular Component: nucleoplasm; transcriptional repressor complex; nucleus

Molecular Function: DNA binding; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; erythrocyte development; establishment and/or maintenance of chromatin architecture; genetic imprinting; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; negative regulation of transcription, DNA-dependent

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