Full Product Name
Cofilin Antibody
Product Synonym Names
18 kDa phosphoprotein; CFL1; COF1; cofilin 1 (non-muscle); Cofilin, non-muscle isoform; Cofilin-1; p18
Product Gene Name
anti-CFL antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y281
Species Reactivity
Human, Mouse, Rat
Specificity
Cofilin Antibody detects endogenous levels of Cofilin
Purity/Purification
Immunogen affinity purified
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human Cofilin
Preparation and Storage
Store at-20 degree C for 1 year
Other Notes
Small volumes of anti-CFL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CFL antibody
cofilin 1 a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described.
Western Blot (WB) of anti-CFL antibody
Western blot analysis on Jurkat cell lysate using Cofilin Antibody
NCBI/Uniprot data below describe general gene information for CFL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001230574.1
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NCBI GenBank Nucleotide #
NM_001243645.1
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UniProt Primary Accession #
Q9Y281
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UniProt Secondary Accession #
G3V5P4[Other Products]
UniProt Related Accession #
Q9Y281[Other Products]
NCBI Official Full Name
cofilin-2 isoform 2
NCBI Official Synonym Full Names
cofilin 2
NCBI Official Symbol
CFL2??[Similar Products]
NCBI Official Synonym Symbols
NEM7
??[Similar Products]
NCBI Protein Information
cofilin-2
UniProt Protein Name
Cofilin-2
UniProt Synonym Protein Names
Cofilin, muscle isoform
UniProt Gene Name
CFL2??[Similar Products]
NCBI Summary for CFL
This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
UniProt Comments for CFL
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere ().
Research Articles on CFL
1. The greatest levels of circulating miR-297 and miR-19b-3p with its common target CFL2 are associated with metastatic prostate cancer.
Precautions
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Disclaimer
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