Product Name
A Cyclase V/VI (ADCY5), Polyclonal Antibody
Full Product Name
A Cyclase V/VI Polyclonal Antibody
Product Gene Name
anti-ADCY5 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O95622
Other Notes
Small volumes of anti-ADCY5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ADCY5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001186571.1
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NCBI GenBank Nucleotide #
NM_001199642.1
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UniProt Primary Accession #
O95622
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UniProt Secondary Accession #
Q7RTV7; Q8NFM3; B7Z8A6[Other Products]
UniProt Related Accession #
O95622[Other Products]
Molecular Weight
102,606 Da[Similar Products]
NCBI Official Full Name
adenylate cyclase type 5 isoform 2
NCBI Official Synonym Full Names
adenylate cyclase 5
NCBI Official Symbol
ADCY5??[Similar Products]
NCBI Official Synonym Symbols
AC5; FDFM
??[Similar Products]
NCBI Protein Information
adenylate cyclase type 5
UniProt Protein Name
Adenylate cyclase type 5
UniProt Synonym Protein Names
ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; AC5
Protein Family
Adenylate cyclase
UniProt Gene Name
ADCY5??[Similar Products]
UniProt Synonym Gene Names
AC5??[Similar Products]
NCBI Summary for ADCY5
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for ADCY5
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca2+ in response to increased blood glucose levels and contributes to the regulation of Ca2+-dependent insulin secretion (PubMed:24740569).
Research Articles on ADCY5
1. Mutations in ADCY5 are responsible for a hyperkinetic movement disorder that can be preceded by episodic attacks before the movement disorder becomes persistent and is frequently misdiagnosed as dyskinetic cerebral palsy.
Precautions
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Disclaimer
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