Full Product Name
ACHB4 Polyclonal Antibody
Product Synonym Names
Neuronal acetylcholine receptor subunit beta-4; CHRNB4
Product Gene Name
anti-ACHB4 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P30926
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 300-380
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-ACHB4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ACHB4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ACHB4 antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for ACHB4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000741.1
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NCBI GenBank Nucleotide #
NM_000750.4
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UniProt Primary Accession #
P30926
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UniProt Secondary Accession #
Q16607; Q4VBA5; Q8WXC8; Q9BQR4; A4FTX5; E9PHE8[Other Products]
UniProt Related Accession #
P30926[Other Products]
NCBI Official Full Name
neuronal acetylcholine receptor subunit beta-4 isoform 1
NCBI Official Synonym Full Names
cholinergic receptor nicotinic beta 4 subunit
NCBI Official Symbol
CHRNB4??[Similar Products]
NCBI Protein Information
neuronal acetylcholine receptor subunit beta-4
UniProt Protein Name
Neuronal acetylcholine receptor subunit beta-4
UniProt Gene Name
CHRNB4??[Similar Products]
NCBI Summary for ACHB4
This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
UniProt Comments for ACHB4
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Research Articles on ACHB4
1. our results show that a genomic region with functionally related genes, such as the CHRNA5/CHRNA3/CHRNB4 cluster, is under coordinated regulatory control.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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