Human SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) ELISA kit; DEL22q13.3; KIAA1650; PROSAP2; PSAP2; SPANK-2; proline rich synapse associated protein 2; proline-rich synapse-associated protein 2; shank postsynaptic density protein; SH3 and multiple ankyrin repeat domains 3

For Research Use Only. Not for use in diagnostic procedures.

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of SHANK3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9317328 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the SH3 and multiple ankyrin repeat domains 3 (SHANK3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SHANK3. The ELISA analytical biochemical technique of the MBS9317328 kit is based on SHANK3 antibody-SHANK3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SHANK3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SHANK3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of CTSB (hereafter termed "analyte") in undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

185,397 Da

SH3/ankyrin domain gene 3

SH3 and multiple ankyrin repeat domains protein 3; SPANK-2; proSAP2; proline-rich synapse-associated protein 2; SH3 and multiple ankyrin repeat domains protein 3 variant c-3; SH3 and multiple ankyrin repeat domains protein 3 variant c-4; SH3 and multiple ankyrin repeat domains-like protein 3 variant 1; SH3 and multiple ankyrin repeat domains-like protein 3 variant 2; SH3 and multiple ankyrin repeat domains-like protein 3 variant 3; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-1

SH3 and multiple ankyrin repeat domains protein 3

Kiaa1650; Prosap2; Shank3; ProSAP2??[Similar Products]

SHANK3: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. A chromosomal aberration involving SHANK3 is found in patients with chromosome 22q13.3 deletion syndrome. Translocation t(12;22)(q24.1;q13.3) with APPL2/DIP13B. Defects in SHANK3 are associated with autism spectrum disorders (ASD). ASD are characterized by impairments in reciprocal social interaction and communication as well as restricted and stereotyped patterns of interest and activities. ASD include forms with moderate to severe cognitive impairment and milder forms with higher cognitive ability (Asperger syndrome). Defects in SHANK3 are the cause of schizophrenia type 15 (SCZD15). SCZD15 is a complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: postsynaptic membrane; neuron projection; cell projection; membrane; cell; postsynaptic density; cytoplasm; plasma membrane; excitatory synapse; synapse; intracellular; cell junction

Molecular Function: protein C-terminus binding; identical protein binding; ionotropic glutamate receptor binding; protein binding; protein self-association; zinc ion binding; GKAP/Homer scaffold activity; actin binding; SH3 domain binding

Biological Process: negative regulation of actin filament bundle formation; MAPKKK cascade; vocal learning; social behavior; learning; positive regulation of long-term neuronal synaptic plasticity; positive regulation of synaptic transmission, glutamatergic; memory; protein oligomerization; positive regulation of synapse structural plasticity; synaptogenesis; striatal medium spiny neuron differentiation; ***** behavior; brain morphogenesis; embryonic epithelial tube formation; neuromuscular process controlling balance; negative regulation of cell volume

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