Product Name
ARHGEF9, Blocking Peptide
Full Product Name
ARHGEF9 Blocking Peptide
Product Synonym Names
ARHDH9; KIAA0424; Rho guanine nucleotide exchange factor 9; Collybistin; PEM-2 homolog; Rac/Cdc42 guanine nucleotide exchange factor 9
Product Gene Name
ARHGEF9 blocking peptide
[Similar Products]
ARHGEF9 peptide (MBS8208527) is used for blocking the activity of ARHGEF9 antibody (MBS8235998)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O43307
Species Reactivity
Human, Mouse, Rat, Bovine
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Directions for Use
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of ARHGEF9 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ARHGEF9 blocking peptide
The peptide is used to block Anti-ARHGEF9 Antibody reactivity.
Applications Tested/Suitable for ARHGEF9 blocking peptide
Blocking (BL)
NCBI/Uniprot data below describe general gene information for ARHGEF9. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001166950.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001173479.1
[Other Products]
UniProt Primary Accession #
O43307
[Other Products]
UniProt Secondary Accession #
Q5JSL6; A8K1S8; B4DHC7; F8W7P8[Other Products]
UniProt Related Accession #
O43307[Other Products]
Molecular Weight
49,458 Da
NCBI Official Full Name
rho guanine nucleotide exchange factor 9 isoform 2
NCBI Official Synonym Full Names
Cdc42 guanine nucleotide exchange factor (GEF) 9
NCBI Official Symbol
ARHGEF9??[Similar Products]
NCBI Official Synonym Symbols
PEM2; EIEE8; PEM-2; HPEM-2; COLLYBISTIN
??[Similar Products]
NCBI Protein Information
rho guanine nucleotide exchange factor 9
UniProt Protein Name
Rho guanine nucleotide exchange factor 9
UniProt Synonym Protein Names
Collybistin; PEM-2 homolog; Rac/Cdc42 guanine nucleotide exchange factor 9
Protein Family
Rho guanine nucleotide exchange factor
UniProt Gene Name
ARHGEF9??[Similar Products]
UniProt Synonym Gene Names
ARHDH9; KIAA0424??[Similar Products]
UniProt Entry Name
ARHG9_HUMAN
NCBI Summary for ARHGEF9
The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. Defects in this gene are a cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
UniProt Comments for ARHGEF9
ARHGEF9: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters. Defects in ARHGEF9 are the cause of pileptic encephalopathy, early infantile, type 8 (EIEE8). A disorder characterized by hyperekplexia and early infantile epileptic encephalopathy. Neurologic features include exaggerated startle response, seizures, impaired psychomotor development, and mental retardation. Seizures can be provoked by tactile stimulation or extreme emotion. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs; GAPs, Rac/Rho
Chromosomal Location of Human Ortholog: Xq11.1
Cellular Component: cytoplasm; cytosol
Molecular Function: Rho guanyl-nucleotide exchange factor activity
Biological Process: synaptic transmission; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; transmembrane transport
Disease: Epileptic Encephalopathy, Early Infantile, 8
Research Articles on ARHGEF9
1. Impairment of the membrane lipid binding activity of Collybistin R290H and a consequent defect in inhibitory synapse maturation represent a likely molecular pathomechanism of epilepsy and mental retardation in humans.
Precautions
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Disclaimer
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