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ARHGEF9, Polyclonal Antibody

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產品名稱: ARHGEF9, Polyclonal Antibody
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ARHGEF9, Polyclonal Antibody


ARHGEF9, Polyclonal Antibody  的詳細介紹
Product Name

ARHGEF9, Polyclonal Antibody

Full Product Name

ARHGEF9 Antibody

Product Synonym Names
COLLYBISTIN antibody; EIEE8 antibody; HPEM-2 antibody; KIAA0424 antibody; PEM-2 antibody; PEM2 antibody; ARHGEF9 antibody; hPEM-2 collybistin antibody; rac/Cdc42 guanine nucleotide exchange factor 9 antibody; rho guanine nucleotide exchange factor 9 antib
Product Gene Name

anti-ARHGEF9 antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
300429
3D Structure
ModBase 3D Structure for O43307
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody detects endogenous levels of total ARHGEF9 protein.
Purity/Purification
Antibodies were purified by antigen-affinity chromatography.
Form/Format
Rabbit IgG in 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration
0.7 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant fragment contain a sequence corresponding to a region within amino acids 133 and 375 of ARHGEF9.
Target Name
ARHGEF9
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ARHGEF9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-ARHGEF9 antibody
ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.[supplied by OMIM]
Product Categories/Family for anti-ARHGEF9 antibody
Total protein Ab
Applications Tested/Suitable for anti-ARHGEF9 antibody
Western Blot (WB)
Application Notes for anti-ARHGEF9 antibody
Western blotting: 1:500-1:3000

Testing Data of anti-ARHGEF9 antibody
Sample (30 ug of whole cell lysate) A: 293T B: HepG2 7.5% SDS PAGE diluted at 1:3000
anti-ARHGEF9 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for ARHGEF9. It may not necessarily be applicable to this product.
NCBI GI #
291045192
NCBI GeneID
23229
NCBI Accession #
NP_001166950.1 [Other Products]
NCBI GenBank Nucleotide #
NM_001173479.1 [Other Products]
UniProt Primary Accession #
O43307 [Other Products]
UniProt Secondary Accession #
Q5JSL6; A8K1S8; B4DHC7; F8W7P8[Other Products]
UniProt Related Accession #
O43307[Other Products]
Molecular Weight
49,458 Da
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NCBI Official Full Name
rho guanine nucleotide exchange factor 9 isoform 2
NCBI Official Synonym Full Names
Cdc42 guanine nucleotide exchange factor (GEF) 9
NCBI Official Symbol
ARHGEF9??[Similar Products]
NCBI Official Synonym Symbols
PEM2; EIEE8; PEM-2; HPEM-2; COLLYBISTIN
??[Similar Products]
NCBI Protein Information
rho guanine nucleotide exchange factor 9
UniProt Protein Name
Rho guanine nucleotide exchange factor 9
UniProt Synonym Protein Names
Collybistin; PEM-2 homolog; Rac/Cdc42 guanine nucleotide exchange factor 9
Protein Family
Rho guanine nucleotide exchange factor
UniProt Gene Name
ARHGEF9??[Similar Products]
UniProt Synonym Gene Names
ARHDH9; KIAA0424??[Similar Products]
UniProt Entry Name
ARHG9_HUMAN
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NCBI Summary for ARHGEF9
The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. Defects in this gene are a cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
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UniProt Comments for ARHGEF9
ARHGEF9: Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters. Defects in ARHGEF9 are the cause of pileptic encephalopathy, early infantile, type 8 (EIEE8). A disorder characterized by hyperekplexia and early infantile epileptic encephalopathy. Neurologic features include exaggerated startle response, seizures, impaired psychomotor development, and mental retardation. Seizures can be provoked by tactile stimulation or extreme emotion. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Rac/Rho; GAPs

Chromosomal Location of Human Ortholog: Xq11.1

Cellular Component: cytoplasm; cytosol

Molecular Function: Rho guanyl-nucleotide exchange factor activity

Biological Process: synaptic transmission; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; transmembrane transport

Disease: Epileptic Encephalopathy, Early Infantile, 8
Research Articles on ARHGEF9
1. Impairment of the membrane lipid binding activity of Collybistin R290H and a consequent defect in inhibitory synapse maturation represent a likely molecular pathomechanism of epilepsy and mental retardation in humans.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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