Anti -CNTNAP2 (Contactin-associated Protein-like 2, Cell Recognition Molecule Caspr2, KIAA0868, CASPR2)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 7; NC_000007.13 (145813453..148118090). Location: 7q35

Polyclonal

IgG

Rabbit

Recognizes human CNTNAP2.

Affinity Purified
Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-CNTNAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CNTNAP2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C omain,discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ . This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons.

Antibodies; Abs to Neuroscience

Western Blot (WB)

Suitable for use in Western Blot.

148,167 Da[Similar Products]

contactin associated protein-like 2

contactin-associated protein-like 2; cell recognition molecule Caspr2; homolog of Drosophila neurexin IV

Contactin-associated protein-like 2

CASPR2; KIAA0868??[Similar Products]

CNTP2_HUMAN

This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ . This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.[provided by RefSeq, Mar 2010]

Function: May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction.

Subunit structure: Associates with KCNA2

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein

Potential.

Tissue specificity: Predominantly expressed in nervous system.

Involvement in disease: Cortical dysplasia-focal epilepsy syndrome (CDFES) [MIM:610042]: A disease characterized by cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7Autism 15 (AUTS15) [MIM:612100]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.A chromosomal aberration involving CNTNAP2 is found in a patient with autism spectrum disorder. Paracentric inversion 46,XY,inv7(q11.22;q35). The inversion breakpoints disrupt the genes AUTS2 and CNTNAP2.

Sequence similarities: Belongs to the neurexin family.Contains 2 EGF-like domains.Contains 1 F5/8 type C domain.Contains 1 fibrinogen C-terminal domain.Contains 4 laminin G-like domains.

Sequence caution: The sequence BAA74891.1 differs from that shown. Reason: Erroneous initiation.

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