Product Name
CNTNAP2, Polyclonal Antibody
Popular Item
Full Product Name
CNTNAP2
Product Gene Name
anti-CNTNAP2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UHC6
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Protein
Other Notes
Small volumes of anti-CNTNAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CNTNAP2 antibody
Polyclonal
Applications Tested/Suitable for anti-CNTNAP2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Western Blot (WB) of anti-CNTNAP2 antibody
Western blot analysis of extracts of mouse brain, using CNTNAP2 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.
NCBI/Uniprot data below describe general gene information for CNTNAP2. It may not necessarily be applicable to this product.
NCBI Accession #
Q9UHC6.1
[Other Products]
UniProt Primary Accession #
Q9UHC6
[Other Products]
UniProt Secondary Accession #
Q14DG2; Q52LV1; Q5H9Q7; Q9UQ12; D3DWG2[Other Products]
UniProt Related Accession #
Q9UHC6[Other Products]
NCBI Official Full Name
Contactin-associated protein-like 2
NCBI Official Synonym Full Names
contactin associated protein-like 2
NCBI Official Symbol
CNTNAP2??[Similar Products]
NCBI Official Synonym Symbols
CDFE; NRXN4; AUTS15; CASPR2; PTHSL1
??[Similar Products]
NCBI Protein Information
contactin-associated protein-like 2; cell recognition molecule Caspr2; homolog of Drosophila neurexin IV
UniProt Protein Name
Contactin-associated protein-like 2
UniProt Synonym Protein Names
Cell recognition molecule Caspr2
Protein Family
Contactin-associated protein
UniProt Gene Name
CNTNAP2??[Similar Products]
UniProt Synonym Gene Names
??[Similar Products]
UniProt Entry Name
CNTP2_HUMAN
NCBI Summary for CNTNAP2
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ . This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.[provided by RefSeq, Mar 2010]
UniProt Comments for CNTNAP2
CNTNAP2: May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction. Associates with KCNA2. Predominantly expressed in nervous system. Belongs to the neurexin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q35
Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; cell surface; cell soma; membrane; axon; early endosome; dendrite; integral to membrane; perikaryon; axolemma
Molecular Function: enzyme binding
Biological Process: striatum development; limbic system development; neuron recognition; transmission of nerve impulse; thalamus development; social behavior; learning; ***** behavior; clustering of voltage-gated potassium channels; brain development; cerebral cortex development; cell adhesion; neurite development
Disease: Autism, Susceptibility To, 15; Cortical Dysplasia-focal Epilepsy Syndrome
Research Articles on CNTNAP2
1. Widespread cortex DNA methylation changes in CNTNAP2 since the human-chimpanzee split, supporting a role for CNTNAP2 fine-regulation in human-specific language and communication traits.
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