Full Product Name
ADCY5 (Adenylate Cyclase Type 5, ATP Pyrophosphate-lyase 5, Adenylate Cyclase Type V, Adenylyl Cyclase 5)
Product Synonym Names
Anti -ADCY5 (Adenylate Cyclase Type 5, ATP Pyrophosphate-lyase 5, Adenylate Cyclase Type V, Adenylyl Cyclase 5)
Product Gene Name
anti-ADCY5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
ADFAMKLMDQ MKYINEHSFN NFQMKIGLNI GPVVAGVIGA RKPQYDIWGN TVNVASRMDS TGVPDRIQVT TDMYQVLAAN TYQLECRGVV KVKGKGEMMT YFLNGGPPLS
Chromosome Location
Chromosome: 3; NC_000003.11 (123001143..123167924, complement). Location: 3q21.1
3D Structure
ModBase 3D Structure for O95622
Specificity
Recognizes human ADCY5.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Partial recombinant corresponding to aa1152-1262 from human ADCY5 (NP_899200) with GST tag. MW of the GST tag alone is 26kD.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ADCY5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ADCY5 antibody
Antibodies; Abs to Enzymes
Applications Tested/Suitable for anti-ADCY5 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ADCY5 antibody
Suitable for use in ELISA and Western Blot.
NCBI/Uniprot data below describe general gene information for ADCY5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001186571.1
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NCBI GenBank Nucleotide #
NM_001199642.1
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UniProt Primary Accession #
O95622
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UniProt Secondary Accession #
Q7RTV7; Q8NFM3; B7Z8A6[Other Products]
UniProt Related Accession #
O95622[Other Products]
Molecular Weight
138,908 Da[Similar Products]
NCBI Official Full Name
adenylate cyclase type 5 isoform 2
NCBI Official Synonym Full Names
adenylate cyclase 5
NCBI Official Symbol
ADCY5??[Similar Products]
NCBI Official Synonym Symbols
AC5; FDFM
??[Similar Products]
NCBI Protein Information
adenylate cyclase type 5; adenylyl cyclase 5; adenylate cyclase type V; ATP pyrophosphate-lyase 5
UniProt Protein Name
Adenylate cyclase type 5
UniProt Synonym Protein Names
ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5
Protein Family
Adenylate cyclase
UniProt Gene Name
ADCY5??[Similar Products]
UniProt Entry Name
ADCY5_HUMAN
NCBI Summary for ADCY5
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for ADCY5
ADCY5: This is a membrane-bound, calcium-inhibitable adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Nucleotide Metabolism - purine; Lyase; Adenylyl cyclase; Membrane protein, integral; Transporter, aquaporin family; Transporter; EC 4.6.1.1
Chromosomal Location of Human Ortholog: 3q21.1
Cellular Component: integral to membrane; plasma membrane
Molecular Function: protein heterodimerization activity; metal ion binding; ATP binding; adenylate cyclase activity; adenylate cyclase binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; locomotory behavior; signal transduction; G-protein signaling, adenylate cyclase activating pathway; dopamine receptor, adenylate cyclase inhibiting pathway; synaptic transmission; phospholipase C activation; energy reserve metabolic process; renal water homeostasis; innate immune response; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; neuromuscular process controlling balance; adenosine receptor signaling pathway; transmembrane transport; dopamine receptor, adenylate cyclase activating pathway
Disease: Dyskinesia, Familial, With Facial Myokymia
Research Articles on ADCY5
1. 2.1) of the variants in GCKR, GIPR, ADCY5 and VPS13C on the response to sulfonylurea treatment, indicating that these variants are not significantly contributing to the risk of SH in patients with T2D">no detectable effect (with an OR >2.1) of the variants in GCKR, GIPR, ADCY5 and VPS13C on the response to sulfonylurea treatment, indicating that these variants are not significantly contributing to the risk of SH in patients with T2D
Precautions
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Disclaimer
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