Full Product Name
ADCY5 Antibody
Product Synonym Names
ATP pyrophosphate-lyase 5; Adenylate cyclase type 5; Adenylate cyclase type V; Adenylyl cyclase 5
Product Gene Name
anti-ADCY5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O95622
Species Reactivity
Human, Mouse, Rat
Specificity
ADCY5 antibody detects endogenous levels of total ADCY5 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human ADCY5.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-ADCY5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ADCY5 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-ADCY5 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ADCY5 antibody
WB: 1:500-1:1000
ELISA: 1:10000
Western Blot (WB) of anti-ADCY5 antibody
Western blot analysis of extracts from COLO205 cells, using ADCY5 antibody.
NCBI/Uniprot data below describe general gene information for ADCY5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001186571.1
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NCBI GenBank Nucleotide #
NM_001199642.1
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UniProt Primary Accession #
O95622
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UniProt Secondary Accession #
Q7RTV7; Q8NFM3; B7Z8A6[Other Products]
UniProt Related Accession #
O95622[Other Products]
Molecular Weight
102,606 Da
NCBI Official Full Name
adenylate cyclase type 5 isoform 2
NCBI Official Synonym Full Names
adenylate cyclase 5
NCBI Official Symbol
ADCY5??[Similar Products]
NCBI Official Synonym Symbols
AC5; FDFM
??[Similar Products]
NCBI Protein Information
adenylate cyclase type 5
UniProt Protein Name
Adenylate cyclase type 5
UniProt Synonym Protein Names
ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; AC5
Protein Family
Adenylate cyclase
UniProt Gene Name
ADCY5??[Similar Products]
UniProt Synonym Gene Names
AC5??[Similar Products]
NCBI Summary for ADCY5
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for ADCY5
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca2+ in response to increased blood glucose levels and contributes to the regulation of Ca2+-dependent insulin secretion (PubMed:24740569).
Product References and Citations for anti-ADCY5 antibody
Muzny D.M., Nature 440:1194-1198(2006). Ludwig M.G., J. Recept. Signal Transduct. Res. 22:79-110(2002). Raimundo S., Clin. Chim. Acta 285:155-161(1999).
Research Articles on ADCY5
1. Mutations in ADCY5 are responsible for a hyperkinetic movement disorder that can be preceded by episodic attacks before the movement disorder becomes persistent and is frequently misdiagnosed as dyskinetic cerebral palsy.
Precautions
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Disclaimer
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