Mouse Homeobox protein Meis1 (MEIS1) ELISA kit; MGC43380; Meis1; myeloid ecotropic viral integration site 1 homolog; WUGSC:H_NH0444B04.1; leukemogenic homolog protein; Meis homeobox 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of MEIS1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9339490 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Meis homeobox 1 (MEIS1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MEIS1. The ELISA analytical biochemical technique of the MBS9339490 kit is based on MEIS1 antibody-MEIS1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MEIS1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MEIS1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

43,002 Da

Meis homeobox 1

homeobox protein Meis1; myeloid ecotropic viral integration site 1

Homeobox protein Meis1

MEIS1_MOUSE

MEIS1: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7). Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. Belongs to the TALE/MEIS homeobox family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Cellular Component: transcription factor complex; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; chromatin binding

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; negative regulation of neuron differentiation; negative regulation of myeloid cell differentiation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; multicellular organismal development; blood vessel morphogenesis; positive regulation of transcription from RNA polymerase II promoter; hemopoiesis; lens morphogenesis in camera-type eye; locomotory behavior; angiogenesis

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