Product Name
MEIS1, Polyclonal Antibody
Popular Item
Full Product Name
MEIS1 Antibody
Product Synonym Names
Homeobox protein Meis1; MEIS1
Product Gene Name
anti-MEIS1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O00470
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant human Homeobox protein Meis1 protein
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-10599 / sc-10596 / sc-25412
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-MEIS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MEIS1 antibody
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
Applications Tested/Suitable for anti-MEIS1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Western Blot (WB) of anti-MEIS1 antibody
Western Blot
Positive WB detected in:Jurkat whole cell lysate,K562 whole cell lysate,Hela whole cell lysate,Mouse skeletal muscle tissue
All lanes: MEIS1 antibody at 2.8ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 44,51 kDa
Observed band size: 44 kDa
Immunohistochemistry (IHC) of anti-MEIS1 antibody
Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7045432 at dilution of 1:100
Immunoprecipitation (IP) of anti-MEIS1 antibody
Immunoprecipitating MEIS1 in K562 whole cell lysate
Lane 1: Rabbit monoclonal IgG (1ug)instead of MBS7045432 in K562 whole cell lysate. For western blotting,a HRP-conjugated Protein G antibody was used as the secondary antibody (1/50000)
Lane 2: MBS7045432 (4ug)+ K562 whole cell lysate (500ug)
Lane 3: K562 whole cell lysate (20ug)
NCBI/Uniprot data below describe general gene information for MEIS1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002389.1
[Other Products]
NCBI GenBank Nucleotide #
NM_002398.2
[Other Products]
UniProt Primary Accession #
O00470
[Other Products]
UniProt Secondary Accession #
A8MV50[Other Products]
UniProt Related Accession #
O00470[Other Products]
Molecular Weight
50,576 Da
NCBI Official Full Name
homeobox protein Meis1
NCBI Official Synonym Full Names
Meis homeobox 1
NCBI Official Symbol
MEIS1??[Similar Products]
NCBI Protein Information
homeobox protein Meis1
UniProt Protein Name
Homeobox protein Meis1
Protein Family
Homeobox protein
UniProt Gene Name
MEIS1??[Similar Products]
UniProt Entry Name
MEIS1_HUMAN
NCBI Summary for MEIS1
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
UniProt Comments for MEIS1
MEIS1: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7). Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. Belongs to the TALE/MEIS homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 2p14
Molecular Function: protein binding
Biological Process: negative regulation of myeloid cell differentiation
Disease: Restless Legs Syndrome, Susceptibility To, 7
Research Articles on MEIS1
1. It was observed that RE-IIBP induces MEIS1-mediated apoptosis, which was dependent on H2BK120 ubiquitination by RNF20.
Precautions
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