Full Product Name
CO2 Polyclonal Antibody
Product Synonym Names
Complement C2; EC 3.4.21.43; C3/C5 convertase; Complement C2b fragment; Complement C2a fragment; C2
Product Gene Name
anti-CO2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P06681
Species Reactivity
Human, Mouse
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-CO2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CO2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CO2 antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for CO2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000054.2
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NCBI GenBank Nucleotide #
NM_000063.5
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UniProt Primary Accession #
P06681
[Other Products]
UniProt Secondary Accession #
O19694; Q13904; B4DPF3; B4DV20; E9PFN7[Other Products]
UniProt Related Accession #
P06681[Other Products]
NCBI Official Full Name
complement C2 isoform 1 preproprotein
NCBI Official Synonym Full Names
complement C2
NCBI Official Symbol
C2??[Similar Products]
NCBI Official Synonym Symbols
CO2; ARMD14
??[Similar Products]
NCBI Protein Information
complement C2
UniProt Protein Name
Complement C2
UniProt Synonym Protein Names
C3/C5 convertase
UniProt Gene Name
C2??[Similar Products]
NCBI Summary for CO2
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]
UniProt Comments for CO2
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
Research Articles on CO2
1. Vag8 binding to human C1-inhibitor (C1-inh) interferes with the binding of C1-inh to C1s, C1r and MASP-2, resulting in the release of active proteases that subsequently cleave C2 and C4 away from the bacterial surface.
Precautions
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Disclaimer
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