Full Product Name
TMC8 antibody - N-terminal region
Product Gene Name
anti-TMC8 antibody
[Similar Products]
Product Synonym Gene Name
EV2; EVER2; EVIN2; MGC102701; MGC40121[Similar Products]
Antibody/Peptide Pairs
TMC8 peptide (MBS3236036) is used for blocking the activity of TMC8 antibody (MBS3211083)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: PGPTLNLTLQ CPGSRQSPPG VLRFHNQLWH VLTGRAFTNT YLFYGAYRVG
3D Structure
ModBase 3D Structure for Q8IU68
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human TMC8
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-TMC8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TMC8 antibody
This is a rabbit polyclonal antibody against TMC8. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.
Product Categories/Family for anti-TMC8 antibody
Polyclonal; Various;
Applications Tested/Suitable for anti-TMC8 antibody
Western Blot (WB)
Western Blot (WB) of anti-TMC8 antibody
WB Suggested Anti-TMC8 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: 721_B cell lysate
NCBI/Uniprot data below describe general gene information for TMC8. It may not necessarily be applicable to this product.
NCBI Accession #
NP_689681
[Other Products]
NCBI GenBank Nucleotide #
NM_152468
[Other Products]
UniProt Primary Accession #
Q8IU68
[Other Products]
UniProt Related Accession #
Q8IU68[Other Products]
NCBI Official Full Name
transmembrane channel-like protein 8
NCBI Official Synonym Full Names
transmembrane channel like 8
NCBI Official Symbol
TMC8??[Similar Products]
NCBI Official Synonym Symbols
EV2; EVER2; EVIN2
??[Similar Products]
NCBI Protein Information
transmembrane channel-like protein 8
UniProt Protein Name
Transmembrane channel-like protein 8
UniProt Synonym Protein Names
Epidermodysplasia verruciformis protein 2
Protein Family
Transmembrane channel-like protein
UniProt Gene Name
TMC8??[Similar Products]
UniProt Synonym Gene Names
EVER2; EVIN2??[Similar Products]
UniProt Entry Name
TMC8_HUMAN
NCBI Summary for TMC8
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]
UniProt Comments for TMC8
TMC8: an endoplasmic reticulum multipass membrane protein. Defects in TMC8 cause Lutz-Lewandowsky epidermodysplasia verruciformis [MIM:226400], a rare skin disease characterized by increased susceptibility to infection by papillomaviruses with an accompanying high risk of skin carcinoma. Three splice-variant isoforms of the human protein have been described.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum membrane; nuclear membrane; endoplasmic reticulum; cytoplasm; integral to membrane
Molecular Function: protein binding; receptor binding
Biological Process: negative regulation of protein oligomerization; zinc ion homeostasis; ion transport; regulation of cell growth; negative regulation of protein binding
Disease: Epidermodysplasia Verruciformis
Research Articles on TMC8
1. The relatively high proportion of EV patients without mutation in TMC6/8 indicates the existence of EV-causing mutations in additional, presently unknown gene(s). However, a homozygous TMC8 splice site mutation in our patients resulted in aberrant transcripts which cannot retain the healthy phenotype
Precautions
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Disclaimer
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