Product Name
TMC8, cDNA Clone
Full Product Name
TMC8 cDNA Clone
Product Gene Name
TMC8 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGCTGCTGC CGCGGTCGGT GTCATCGGAG CGGGCCCCTG GGGTGCCGGA GCCGGAGGAG CTGTGGGAGG CAGAGATGGA GCGGCTGCGC GGCTCTGGGA CGCCCGTGCG CGGGCTGCCC TATGCCATGA TGGACAAGCG CCTCATCTGG CAGCTGCGGG AGCCCGTGGG GGTGCAGACC TTGCGCTGGC AGCGGTGGCA GCGCCGGCGG CAGACGGTGG AAAGGCGCCT GCGGGAGGCA GCGCAGCGGC TGGCCCGGGG CCTTGGGCTC TGGGAGGGGG CGCTCTACGA GATCGGGGGC CTCTTCGGCA CAGGAATTCG GTCCTACTTC ACCTTCCTCC GCTTCCTGCT GCTACTCAAC CTGCTGAGCC TGCTGCTCAC CGCAAGCTTC GTGCTGCTGC CCCTGGTCTG GCTCCGCCCC CCTGACCCAG GCCCCACCCT GAACTTGACC CTCCAGTGCC CTGGTAGCCG CCAGTCCCCG CCTGGCGTTT TGAGGTTCCA CAATCAACTT TGGCATGTTT TGACTGGCAG GGCCTTCACC AACACCTATC TCTTCTACGG TGCGTACCGA GTGGGGCCGG AGAGCAGCTC CGTGTACAGC ATCCGCCTGG CCTACCTCCT CAGCCCGCTG GCCTGCCTGC TCCTCTGCTT CTGTGGGACT CTGCGGCGGA TGGTGAAGGG GCTGCCGCAG AAGACTCTGC TGGGTCAGGG CTATCAGGCG CCTCTCAGCG CCAAGGTCTT CTCCTCATGG GACTTCTGCA TCCGGGTGCA GGAAGCAGCC ACCATCAAGA AGCATGAGAT CAGCAACGAG TTCAAGGTGG AGCTGGAGGA GGGCCGTCGC TTCCAGCTGA TGCAGCAGCA GACCCGGGCC CAGACGGCCT GCCGCCTGCT CTCCTACCTG CGGGTCAACG TACTCAACGG GCTCCTGGTG GTTGGGGCCA TCAGCGCCAT CTTCTGGGCT ACCAAGTACT CACAGGACAA CAAGGAGGAG TCCCTGTTTC TGCTGCTCCA GTACCTGCCC CCTGGGGTCA TCGCCCTGGT CAACTTCCTG GGTCCCCTGC TGTTCACATT TCTGGTCCAG CTGGAGAACT ACCCTCCCAA CACGGAGGTC AACCTCACTC TGATCTGGTG CGTGGTGCTG AAGCTGGCCA GCTTGGGGAT GTTCTCCGTC TCCCTGGGTC AGACCATACT GTGCATTGGC AGAGACAAGA GCAGCTGTGA GTCCTACGGC TACAACGTTT GTGACTATCA GTGCTGGGAG AACTCCGTGG GGGAGGAGCT GTACAAGCTG AGTATCTTCA ACTTCCTCCT CACCGTGGCC TTCGCCTTCC TGGTCACCCT GCCTCGGAGG CTGCTGGTGG ACCGGTTCTC AGGCCGGTTC TGGGCCTGGC TGGAACGGGA GGAGTTCCTG GTCCCCAAGA ATGTGCTGGA CATCGTGGCG GGGCAGACGG TCACCTGGAT GGGCCTCTTC TACTGCCCCC TGCTGCCCCT GCTGAATAGC GTCTTCCTCT TCCTCACCTT CTACATCAAG AAGTACACCC TCCTGAAGAA CTCCAGGGCA TCTTCGCGGC CCTTCCGTGC CTCCAGCTCC ACCTTCTTCT TCCAGCTAGT GCTCCTCCTG GGCCTGCTTC TGGCTGCAGT GCCCCTGGGC TATGTGGTCA GCAGCATCCA CTCCTCCTGG GACTGCGGCC TCTTCACCAA CTACTCAGCA CCCTGGCAAG TGGTCCCGGA GCTGGTGGCC CTTGGGCTCC CGCCCATTGG CCAGCGTGCC CTCCACTACC TGGGCTCCCA CGCCTTCAGC TTCCCCCTCC TCATCATGCT CAGCCTTGTC CTGACGGTGT GCGTCTCCCA GACCCAGGCC AATGCCAGGG CCATCCACAG GCTCCGGAAG CAGCTGGTGT GGCAGGTTCA GGAGAAGTGG CACCTGGTGG AGGACCTGTC GCGACTGCTG CCGGAGCCAG GCCCGAGCGA CTCTCCGGGC CCCAAGTACC CTGCCTCCCA AGCTTCGCGC CCGCAGTCCT TCTGCCCCGG ATGCCCATGC CCTGGCTCCC CGGGCCACCA GGCCCCGCGG CCGGGCCCCT CCGTCGTGGA TGCCGCGGGA CTGCGTTCCC CTTGCCCTGG ACAGCACGGT GCCCCGGCCT CCGCCCGCAG ATTCCGCTTC CCCAGCGGCG CGGAGCTGTA A
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of TMC8 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TMC8. It may not necessarily be applicable to this product.
NCBI Accession #
BC141865
[Other Products]
UniProt Secondary Accession #
Q2YDC0; Q8IWU7; Q8N358; Q8NF04[Other Products]
UniProt Related Accession #
Q8IU68[Other Products]
Molecular Weight
56,132 Da
NCBI Official Full Name
Homo sapiens transmembrane channel-like 8, mRNA
NCBI Official Synonym Full Names
transmembrane channel like 8
NCBI Official Symbol
TMC8??[Similar Products]
NCBI Official Synonym Symbols
EV2; EVER2; EVIN2
??[Similar Products]
NCBI Protein Information
transmembrane channel-like protein 8
UniProt Protein Name
Transmembrane channel-like protein 8
UniProt Synonym Protein Names
Epidermodysplasia verruciformis protein 2
Protein Family
Transmembrane channel-like protein
UniProt Gene Name
TMC8??[Similar Products]
UniProt Synonym Gene Names
EVER2; EVIN2??[Similar Products]
UniProt Entry Name
TMC8_HUMAN
NCBI Summary for TMC8
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]
UniProt Comments for TMC8
TMC8: an endoplasmic reticulum multipass membrane protein. Defects in TMC8 cause Lutz-Lewandowsky epidermodysplasia verruciformis [MIM:226400], a rare skin disease characterized by increased susceptibility to infection by papillomaviruses with an accompanying high risk of skin carcinoma. Three splice-variant isoforms of the human protein have been described.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: cytoplasm; endoplasmic reticulum; extracellular space; Golgi apparatus; nuclear membrane
Molecular Function: protein binding; receptor binding
Biological Process: negative regulation of protein binding; negative regulation of protein oligomerization; regulation of cell growth; zinc ion homeostasis
Disease: Epidermodysplasia Verruciformis
Research Articles on TMC8
1. TMC6/EVER1 and TMC8/EVER2 are known to be involved in the development of EV.
Precautions
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Disclaimer
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