Full Product Name
Rabbit TMC8 Antibody
Product Gene Name
anti-TMC8 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (76126859..76139049). Location: 17q25.3
3D Structure
ModBase 3D Structure for Q8IU68
Species Reactivity
Human, mouse, rat
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-TMC8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TMC8 antibody
Immunohistochemistry (IHC), ELISA (EIA)
NCBI/Uniprot data below describe general gene information for TMC8. It may not necessarily be applicable to this product.
NCBI Accession #
NP_689681.2
[Other Products]
NCBI GenBank Nucleotide #
NM_152468.4
[Other Products]
UniProt Primary Accession #
Q8IU68
[Other Products]
UniProt Secondary Accession #
Q2YDC0; Q8IWU7; Q8N358; Q8NF04[Other Products]
UniProt Related Accession #
Q8IU68[Other Products]
Molecular Weight
81,641 Da
NCBI Official Full Name
transmembrane channel-like protein 8
NCBI Official Synonym Full Names
transmembrane channel-like 8
NCBI Official Symbol
TMC8??[Similar Products]
NCBI Official Synonym Symbols
EV2; EVER2; EVIN2
??[Similar Products]
NCBI Protein Information
transmembrane channel-like protein 8; epidermodysplasia verruciformis 2; epidermodysplasia verruciformis protein 2
UniProt Protein Name
Transmembrane channel-like protein 8
UniProt Synonym Protein Names
Epidermodysplasia verruciformis protein 2
Protein Family
Transmembrane channel-like protein
UniProt Gene Name
TMC8??[Similar Products]
UniProt Synonym Gene Names
EVER2; EVIN2??[Similar Products]
UniProt Entry Name
TMC8_HUMAN
NCBI Summary for TMC8
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]
UniProt Comments for TMC8
TMC8: an endoplasmic reticulum multipass membrane protein. Defects in TMC8 cause Lutz-Lewandowsky epidermodysplasia verruciformis [MIM:226400], a rare skin disease characterized by increased susceptibility to infection by papillomaviruses with an accompanying high risk of skin carcinoma. Three splice-variant isoforms of the human protein have been described.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum membrane; nuclear membrane; endoplasmic reticulum; cytoplasm; integral to membrane
Molecular Function: protein binding; receptor binding
Biological Process: negative regulation of protein oligomerization; zinc ion homeostasis; ion transport; regulation of cell growth; negative regulation of protein binding
Disease: Epidermodysplasia Verruciformis
Research Articles on TMC8
1. EVER2-deficient patients display mild T-cell abnormalities: a significant increase of memory CD4+ and effector memory CD8+ T cells, a bias of the T cell receptor Valphabeta and Vgammadelta repertoires and an increase of skin-homing CD4+ T-cell subsets.
Precautions
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Disclaimer
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