Full Product Name
ADCY5 Antibody - middle region
Product Gene Name
anti-ADCY5 antibody
[Similar Products]
Product Synonym Gene Name
AC5; FDFM[Similar Products]
Antibody/Peptide Pairs
ADCY5 peptide (MBS3248579) is used for blocking the activity of ADCY5 antibody (MBS3224265)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: EELQAYNRRL LHNILPKDVA AHFLARERRN DELYYQSCEC VAVMFASIAN
3D Structure
ModBase 3D Structure for O95622
Purity/Purification
Affinity purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human ADCY5
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ADCY5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ADCY5 antibody
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene.
Product Categories/Family for anti-ADCY5 antibody
Polyclonal; Cell Biology;
Applications Tested/Suitable for anti-ADCY5 antibody
Western Blot (WB)
Western Blot (WB) of anti-ADCY5 antibody
Host: Rabbit
Target Name: ADCY5
Sample Tissue: Human 786-0 Whole Cell lysates
Antibody Dilution: 1ug/ml
NCBI/Uniprot data below describe general gene information for ADCY5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001186571.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001199642.1
[Other Products]
UniProt Primary Accession #
O95622
[Other Products]
UniProt Related Accession #
O95622[Other Products]
NCBI Official Full Name
adenylate cyclase type 5 isoform 2
NCBI Official Synonym Full Names
adenylate cyclase 5
NCBI Official Symbol
ADCY5??[Similar Products]
NCBI Official Synonym Symbols
AC5; FDFM
??[Similar Products]
NCBI Protein Information
adenylate cyclase type 5
UniProt Protein Name
Adenylate cyclase type 5
UniProt Synonym Protein Names
ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; AC5
Protein Family
Adenylate cyclase
UniProt Gene Name
ADCY5??[Similar Products]
UniProt Synonym Gene Names
AC5??[Similar Products]
NCBI Summary for ADCY5
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for ADCY5
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca2+ in response to increased blood glucose levels and contributes to the regulation of Ca2+-dependent insulin secretion (PubMed:24740569).
Research Articles on ADCY5
1. Depression and psychosis are described as a part of the ADCY5-related dyskinesia phenotypic spectrum.
Precautions
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Disclaimer
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