Product Name
ADCY5/6, Polyclonal Antibody
Full Product Name
ADCY5/6 Antibody
Product Synonym Names
ATP pyrophosphate-lyase 5; Adenylate cyclase type 5; Adenylate cyclase type V; Adenylyl cyclase 5
Product Gene Name
anti-ADCY5/6 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O95622
Species Reactivity
Human, Mouse, Rat
Specificity
ADCY5/6 Antibody detects endogenous levels of total ADCY5/6 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human ADCY5/6.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-ADCY5/6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ADCY5/6 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ADCY5/6 antibody
WB: 1:500~1:1000
ELISA: 1:10000
Western Blot (WB) of anti-ADCY5/6 antibody
Western blot analysis of lysates from COLO205 cells, using ADCY5/6 Antibody. The lane on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for ADCY5/6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001186571.1
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NCBI GenBank Nucleotide #
NM_001199642.1
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UniProt Primary Accession #
O95622
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UniProt Secondary Accession #
Q7RTV7; Q8NFM3; B7Z8A6[Other Products]
UniProt Related Accession #
O95622[Other Products]
NCBI Official Full Name
adenylate cyclase type 5 isoform 2
NCBI Official Synonym Full Names
adenylate cyclase 5
NCBI Official Symbol
ADCY5??[Similar Products]
NCBI Official Synonym Symbols
AC5; FDFM
??[Similar Products]
NCBI Protein Information
adenylate cyclase type 5
UniProt Protein Name
Adenylate cyclase type 5
UniProt Synonym Protein Names
ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; AC5
UniProt Gene Name
ADCY5??[Similar Products]
UniProt Synonym Gene Names
AC5??[Similar Products]
NCBI Summary for ADCY5/6
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for ADCY5/6
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca2+ in response to increased blood glucose levels and contributes to the regulation of Ca2+-dependent insulin secretion (PubMed:24740569).
Research Articles on ADCY5/6
1. ADCY5 gene mutations can present with a wider variety of movement disorder syndromes.
Precautions
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Disclaimer
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