Full Product Name
MEIS1 Antibody - middle region
Product Gene Name
anti-MEIS1 antibody
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Antibody/Peptide Pairs
MEIS1 peptide (MBS3247768) is used for blocking the activity of MEIS1 antibody (MBS3223121)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: PSSGGHTSHS GDNSSEQGDG LDNSVASPST GDDDDPDKDK KRHKKRGIFP
3D Structure
ModBase 3D Structure for O00470
Purity/Purification
Affinity purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human MEIS1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-MEIS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MEIS1 antibody
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.
Product Categories/Family for anti-MEIS1 antibody
Polyclonal; Transcription Factor; Cancer; Transcription Regulation; Developmental Biology;
Applications Tested/Suitable for anti-MEIS1 antibody
Western Blot (WB)
Western Blot (WB) of anti-MEIS1 antibody
Host: Rabbit
Target Name: MEIS1
Sample Tissue: Human 786-0 Whole Cell lysates
Antibody Dilution: 1ug/ml
NCBI/Uniprot data below describe general gene information for MEIS1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002389.1
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NCBI GenBank Nucleotide #
NM_002398.2
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UniProt Primary Accession #
O00470
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UniProt Related Accession #
O00470[Other Products]
NCBI Official Full Name
homeobox protein Meis1
NCBI Official Synonym Full Names
Meis homeobox 1
NCBI Official Symbol
MEIS1??[Similar Products]
NCBI Protein Information
homeobox protein Meis1
UniProt Protein Name
Homeobox protein Meis1
Protein Family
Homeobox protein
UniProt Gene Name
MEIS1??[Similar Products]
UniProt Entry Name
MEIS1_HUMAN
NCBI Summary for MEIS1
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
UniProt Comments for MEIS1
MEIS1: Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7). Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. Belongs to the TALE/MEIS homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 2p14
Cellular Component: nucleus; transcription factor complex
Molecular Function: chromatin binding; protein binding; protein heterodimerization activity; RNA polymerase II transcription factor activity, enhancer binding
Biological Process: angiogenesis; lens morphogenesis in camera-type eye; locomotory behavior; negative regulation of myeloid cell differentiation; negative regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Disease: Restless Legs Syndrome, Susceptibility To, 7
Research Articles on MEIS1
1. TAL1 mediates the function of MEIS1 in hemogenic endothelial progenitors specification. In addition, MEIS1 is vital for megakaryopoiesis and thrombopoiesis from hPSCs. Mechanistically, FLI1 acts as a downstream gene necessary for the function of MEIS1 during megakaryopoiesis
Precautions
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Disclaimer
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