Full Product Name
Anti-MEIS1 Rabbit pAb
Product Synonym Names
Homeo box protein Meis1; Leukemogenic homolog protein; MEIS 1; Meis homeo box 1; Meis1; Meis1 mouse homolog; MEIS1 protein
Product Gene Name
anti-MEIS1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O00470
Species Reactivity
Human, Mouse, Rat
Specificity
MEIS1 Antibody detects endogenous levels of total MEIS1
Purity/Purification
Affinity Chromatography
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human MEIS1
Subcellular Location
Nucleus
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Other Notes
Small volumes of anti-MEIS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MEIS1 antibody
MEIS proteins belong to the TALE (Three Amino Acid Loop Extension) homeobox containing transcription factor family. MEIS1 has been associated with leukemogenesis and neuroblastoma.
Applications Tested/Suitable for anti-MEIS1 antibody
Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Application Notes for anti-MEIS1 antibody
WB: 1:1000-1:5000
IP: 1:50
FC/FACS: 1:50
Western Blot (WB) of anti-MEIS1 antibody
Western blot analysis of MEIS1 expression in K562 cell lysate.
NCBI/Uniprot data below describe general gene information for MEIS1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002389.1
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NCBI GenBank Nucleotide #
NM_002398.2
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UniProt Primary Accession #
O00470
[Other Products]
UniProt Secondary Accession #
A8MV50[Other Products]
UniProt Related Accession #
O00470[Other Products]
NCBI Official Full Name
homeobox protein Meis1
NCBI Official Synonym Full Names
Meis homeobox 1
NCBI Official Symbol
MEIS1??[Similar Products]
NCBI Protein Information
homeobox protein Meis1
UniProt Protein Name
Homeobox protein Meis1
Protein Family
Homeobox protein
UniProt Gene Name
MEIS1??[Similar Products]
NCBI Summary for MEIS1
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
UniProt Comments for MEIS1
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
Research Articles on MEIS1
1. By investigating the role of MEIS1 in ccRCC cells' survival, proliferation, anchorage-independent growth, cell cycle progress, apoptosis and metastasis, in the present work, we propose that MEIS1 may play an important role in clear cell renal cell carcinoma (ccRCC) development.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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