Product Name
COP9 signalosome complex subunit 2 (alien), Recombinant Protein
Full Product Name
Recombinant Drosophila melanogaster COP9 signalosome complex subunit 2 (alien)
Product Gene Name
alien recombinant protein
[Similar Products]
Product Synonym Gene Name
alien[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-444aa, full length protein
Sequence
MSDNDDDFMC DDDEDYGLEY SEDSNSEPDV DLENQYYNSK ALKEEEPKAA LASFQKVLDL ENGEKGEWGF KALKQMIKIN FRLCNYDEMM VRYKQLLTYI KSAVTRNHSE KSINSILDYI STSKNMALLQ NFYETTLDAL RDAKNDRLWF KTNTKLGKLY FDRSDFTKLQ KILKQLHQSC QTDDGEDDLK KGTQLLEIYA LEIQMYTVQK NNKKLKALYE QSLHIKSAIP HPLIMGVIRE CGGKMHLREG EFEKAHTDFF EAFKNYDESG SPRRTTCLKY LVLANMLMKS GINPFDSQEA KPYKNDPEIL AMTNLVNSYQ NNDINEFETI LRQHRSNIMA DQFIREHIED LLRNIRTQVL IKLIRPYKNI AIPFIANALN IEPAEVESLL VSCILDDTIK GRIDQVNQVL QLDKINSSAS RYNALEKWSN QIQSLQFAVV QKMA
3D Structure
ModBase 3D Structure for Q94899
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Drosophila melanogaster (Fruit fly)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of alien recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for alien. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001260276.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001273347.1
[Other Products]
UniProt Primary Accession #
Q94899
[Other Products]
UniProt Secondary Accession #
Q8MSX8; Q9V3Z0; A4V0G9[Other Products]
UniProt Related Accession #
Q94899[Other Products]
Molecular Weight
51,527 Da
NCBI Official Full Name
alien, isoform D
NCBI Official Symbol
alien??[Similar Products]
NCBI Official Synonym Symbols
Alien; BcDNA:LD10463; CG9556; CH2; Csn2; CSN2; Dch2; DCH2; DmelCG9556
??[Similar Products]
NCBI Protein Information
CG9556 gene product from transcript CG9556-RD
UniProt Protein Name
COP9 signalosome complex subunit 2
UniProt Synonym Protein Names
Alien protein
UniProt Gene Name
alien??[Similar Products]
UniProt Synonym Gene Names
Dch2; Signalosome subunit 2??[Similar Products]
UniProt Comments for alien
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.
Research Articles on alien
1. Alien seems to modulate nucleosome assembly activity. This suggests that Alien is acting on chromatin not only through recruitment of histone-modifying activities, but also through enhancing nucleosome assembly.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
