Product Name
Contactin-associated protein-like 2 (Cntnap2), Recombinant Protein
Full Product Name
Recombinant Mouse Contactin-associated protein-like 2 (Cntnap2) , partial
Product Gene Name
Cntnap2 recombinant protein
[Similar Products]
Product Synonym Gene Name
Cntnap2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9CPW0
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Cntnap2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Cntnap2 recombinant protein
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5
8 type C domain, discoidin
neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ . This protein is localized at the juxtaparanodes of myelinated axons and associated with potassium channels. It may play a role in the local differentiation of the axon into distinct functional subdomains. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It may represent a positional candidate gene for the DFNB13 form of nonsyndromic deafness.
NCBI/Uniprot data below describe general gene information for Cntnap2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001004357.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001004357.2
[Other Products]
UniProt Primary Accession #
Q9CPW0
[Other Products]
UniProt Secondary Accession #
Q6P2K4; Q6ZQ31[Other Products]
UniProt Related Accession #
Q9CPW0[Other Products]
Molecular Weight
11,899 Da
NCBI Official Full Name
contactin-associated protein-like 2 isoform a
NCBI Official Synonym Full Names
contactin associated protein-like 2
NCBI Official Symbol
Cntnap2??[Similar Products]
NCBI Official Synonym Symbols
Caspr2; mKIAA0868; 5430425M22Rik
??[Similar Products]
NCBI Protein Information
contactin-associated protein-like 2
UniProt Protein Name
Contactin-associated protein-like 2
UniProt Synonym Protein Names
Cell recognition molecule Caspr2
Protein Family
Contactin-associated protein
UniProt Gene Name
Cntnap2??[Similar Products]
UniProt Synonym Gene Names
Kiaa0868??[Similar Products]
UniProt Comments for Cntnap2
Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons (PubMed:25378149). Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction (Probable) (PubMed:25378149).
Research Articles on Cntnap2
1. Cntnap2 KO rats exhibited severe motor seizures, hyperactivity, and increased consolidation of wakefulness and REM sleep. By contrast, Cntnap2 KO mice demonstrated absence seizure-like events, hypoactivity, and wake fragmentation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
