Product Name
BACH1/BRIP1, Polyclonal Antibody
Full Product Name
Phospho-BACH1/BRIP1 (Thr1133) Antibody
Product Synonym Names
ATP dependent RNA helicase BRIP1; ATP-dependent RNA helicase BRIP1; BACH 1; BRAC 1 Associated C Terminal Helicase 1; BRCA 1 Interacting Protein 1; BRCA1 binding helicase like protein BACH1; BRCA1 interacting protein C terminal helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1/BRCA2 associated helicase 1; BRIP 1; BRIP1; FANCJ; FANCJ_HUMAN; Fanconi anemia group J protein; FLJ90232; MGC126521; MGC126523; OF; Protein FACJ
Product Gene Name
anti-BACH1/BRIP1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9BX63
Purity/Purification
Purified rabbit serum by affinity purification via sequential chromatography on phospho-and non-phospho-peptide affinity columns.
Immunogen
A synthesized peptide derived from human BACH1/BRIP1 around the phosphorylation site of Thr1133
Storage Buffer
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Other Notes
Small volumes of anti-BACH1/BRIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BACH1/BRIP1 antibody
Western Blot (WB)
Application Notes for anti-BACH1/BRIP1 antibody
WB: 1:500-1:2000
NCBI/Uniprot data below describe general gene information for BACH1/BRIP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_114432.2
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NCBI GenBank Nucleotide #
NM_032043.2
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UniProt Primary Accession #
Q9BX63
[Other Products]
UniProt Secondary Accession #
Q3MJE2; Q8NCI5[Other Products]
UniProt Related Accession #
Q9BX63[Other Products]
NCBI Official Full Name
Fanconi anemia group J protein
NCBI Official Synonym Full Names
BRCA1 interacting protein C-terminal helicase 1
NCBI Official Symbol
BRIP1??[Similar Products]
NCBI Official Synonym Symbols
OF; BACH1; FANCJ
??[Similar Products]
NCBI Protein Information
Fanconi anemia group J protein
UniProt Protein Name
Fanconi anemia group J protein
UniProt Synonym Protein Names
ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1-interacting protein 1
UniProt Gene Name
BRIP1??[Similar Products]
UniProt Synonym Gene Names
BACH1; FANCJ; Protein FACJ; BRCA1-interacting protein 1??[Similar Products]
NCBI Summary for BACH1/BRIP1
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]
UniProt Comments for BACH1/BRIP1
DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.
Research Articles on BACH1/BRIP1
1. LOH may predominantly indicate copy number gains in FANCF and losses in FANCG and BRIP1. Integration of copy number data and gene expression proved difficult as the available sample sets did not overlap.
Precautions
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Disclaimer
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