Product Name
(Rhesus macaque) Galactocerebrosidase (GALC), Recombinant Protein
Full Product Name
Recombinant Macaca mulatta (Rhesus macaque) Galactocerebrosidase (GALC)
Product Synonym Names
Recombinant (Rhesus macaque) Galactocerebrosidase (GALC); Galactocerebrosidase; GALCERase EC= 3.2.1.46; Galactocerebroside beta-galactosidase Galactosylceramidase Galactosylceramide beta-galactosidase
Product Gene Name
GALC recombinant protein
[Similar Products]
Product Synonym Gene Name
GALC[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
43-685
Sequence
YVLDDSDGLG REFDGIGAVS GGGATSRLLV NYPEPYRSQI LDYLFKPNFG ASLHILKVEI GGDGQTTDGT EPSHMHYALD ENYFRGYEWW LMKEAKKRNP NITLIGLPWS FPGWLGKGFD WPYVNLQLTA YYVVTWIVGA KRYHDLDIDY IGIWNERSYN ANYIKILRKM LNSQGLQRVK IIASDNLWES ISAAMLLDAE LFKVVDVIGA HYPGTHSVKD ARLTGKKLWS SEDFSTLNSD TGAGCWGRIL NQNYVNGYMT STIAWNLVAS YYEQLPYGRC GLMTAQEPWS GHYVVESPVW VSAHTTQFTQ PGWYYLKTVG HLEKGGSYVA LTDGLGNLTI IIETMSHKHS KCIRPFLPYF NVSQQFATFV LKGSFSEIPE LQVWYTKLGK TSERFLFKQL DSLWLLDSNG SFTLKLQEDE LFTLTTLTTG RKGSYLPPPK SQRFPSTYKD DFNVDYPFFS EAPNFADQTG VFEYFTNMED PGEHHFTLRQ VLNQRPITWA ADASNTISII GDYNWTNLTI KCDVYIETPD TGGVFIAGRV NKGGILIRSA RGIFFWIFAN GSYRVTGDLA GWIIYALGHV EVTAKTWYTL TLTIKGRFAS GMLNDKSLWT DIPVNFPKNG WAAIGTHSFE FAQFDNFHVE ATR
Chromosome Location
Chromosome: 7; NC_007864.1 (151114169..151171568, complement). Location: chromosome: 7
3D Structure
ModBase 3D Structure for O02791
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Macaca mulatta (Rhesus macaque)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of GALC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for GALC. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001037727.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001044262.2
[Other Products]
UniProt Primary Accession #
O02791
[Other Products]
UniProt Related Accession #
O02791[Other Products]
Molecular Weight
77,090 Da[Similar Products]
NCBI Official Full Name
galactocerebrosidase
NCBI Official Symbol
GALC??[Similar Products]
NCBI Protein Information
galactocerebrosidase; GALCERase; galactocerebroside beta-galactosidase; galactosylceramide beta-galactosidase
UniProt Protein Name
Galactocerebrosidase
UniProt Synonym Protein Names
Galactocerebroside beta-galactosidase; Galactosylceramidase; Galactosylceramide beta-galactosidase
Protein Family
Galactocerebrosidase
UniProt Gene Name
GALC??[Similar Products]
UniProt Synonym Gene Names
GALCERase??[Similar Products]
UniProt Entry Name
GALC_MACMU
UniProt Comments for GALC
Function: Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon
By similarity.
Catalytic activity: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.
Subcellular location: Lysosome
By similarity.
Involvement in disease: Note=Defects in GALC are the cause of globoid cell leukodystrophy (GLD); also known as Krabbe disease. This deficiency results in the insufficient catabolism of several galactolipids that are important in the production of normal myelin.
Sequence similarities: Belongs to the glycosyl hydrolase 59 family.
Caution: It is uncertain whether Met-1 or Met-17 is the initiator.
Sequence caution: The sequence AAB58575.1 differs from that shown. Reason: Erroneous initiation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
