Rat Neurexin-1-alpha (NRXN1) ELISA kit; DKFZp313P2036; FLJ35941; Hs.22998; KIAA0578; OTTHUMP00000200525; neurexin I; neurexin 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of NRXN1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9319813 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the neurexin 1 (NRXN1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NRXN1. The ELISA analytical biochemical technique of the MBS9319813 kit is based on NRXN1 antibody-NRXN1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NRXN1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NRXN1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

167,923 Da

neurexin 1

neurexin 1; neurexin I-beta; neurexin-1-beta; neurexin I-alpha; neurexin-1-alpha; non-processed neurexin I-alpha

Neurexin-1

NRX1A_RAT

neuronal cell recognition molecule; may have a role in synaptogenesis [RGD, Feb 2006]

NRXN1: Cell surface protein involved in cell-cell-interactions, excytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)- triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latroxin from spider venom. Belongs to the neurexin family. 4 isoforms of the human protein are produced by alternative promoter.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: presynaptic membrane; cell surface; endocytic vesicle; cell; integral to membrane; plasma membrane; cell junction

Molecular Function: protein binding; calcium channel regulator activity; acetylcholine receptor binding; calcium ion binding; cell adhesion molecule binding; calcium-dependent protein binding; receptor binding

Biological Process: prepulse inhibition; neurotransmitter secretion; vocal learning; learning; social behavior; positive regulation of synaptic transmission, glutamatergic; cerebellar granule cell differentiation; negative regulation of filopodium formation; heterophilic cell adhesion; synaptic transmission; positive regulation of synaptogenesis; establishment of protein localization; synaptogenesis; ***** behavior; calcium-dependent cell-cell adhesion; protein heterotetramerization; neuron adhesion; angiogenesis; cell adhesion; neuromuscular process controlling balance; vesicle docking during exocytosis

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