5-HT-3; 5-HT3R; 5-hydroxytryptamine 3 receptor; 5HT3R; HTR3

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous levels of total 5-HT-3A protein.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1.0 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-5-HT-3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.Miyake A., Mol. Pharmacol. 48:407-416(1995).Belelli D., Mol. Pharmacol. 48:1054-1062(1995).Yamada K., Biol. Psychiatry 60:192-201(2006).

Total protein Ab

Western Blot (WB)

Western blotting: 1:500~1:3000

Western blot analysis of extracts from HT-29 cells, using 5-HT-3A antibody.

59,002 Da

5-hydroxytryptamine (serotonin) receptor 3A, ionotropic

5-hydroxytryptamine receptor 3A

5-hydroxytryptamine receptor 3A

5HT3R; HTR3; 5-HT3-A; 5-HT3A; 5-HT-3; 5-HT3R??[Similar Products]

5HT3A_HUMAN

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

5-HT(3): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Transporter, ion channel; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: postsynaptic membrane; cell soma; integral to plasma membrane; axon; cytoplasm; plasma membrane; cell junction

Molecular Function: serotonin binding; serotonin-activated cation-selective channel activity; voltage-gated potassium channel activity; serotonin receptor activity; receptor activity

Biological Process: synaptic transmission; response to ethanol; transport; digestion; response to cocaine; transmembrane transport; serotonin receptor signaling pathway

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