Product Name
Neuroserpin (SERPINI1), Recombinant Protein
Full Product Name
Recombinant Chicken Neuroserpin (SERPINI1)
Product Gene Name
SERPINI1 recombinant protein
[Similar Products]
Product Synonym Gene Name
SERPINI1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
17-410aa, Full Length of Mature Protein
Sequence
FKTNFPDETI AELSVNVYNQ LRAAREDENI LFCPLSIAIA MGMIELGAHG TTLKEIRHSL GFDSLKNGEE FTFLKDLSDM ATTEESHYVL NMANSLYVQN GFHVSEKFLQ LVKKYFKAEV ENIDFSQSAA VATHINKWVE NHTNNMIKDF VSSRDFSALT HLVLINAIYF KGNWKSQFRP ENTRTFSFTK DDETEVQIPM MYQQGEFYYG EFSDGSNEAG GIYQVLEIPY EGDEISMMIV LSRQEVPLVT LEPLVKASLI NEWANSVKKQ KVEVYLPRFT VEQEIDLKDV LKGLGITEVF SRSADLTAMS DNKELYLAKA FHKAFLEVNE EGSEAAAASG MIAISRMAVL YPQVIVDHPF FFLVRNRRTG TVLFMGRVMH PEAMNTSGHD FEEL
3D Structure
ModBase 3D Structure for Q90935
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SERPINI1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SERPINI1 recombinant protein
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
NCBI/Uniprot data below describe general gene information for SERPINI1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001004411.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001004411.1
[Other Products]
UniProt Primary Accession #
Q90935
[Other Products]
UniProt Secondary Accession #
A0A1I7Q408[Other Products]
UniProt Related Accession #
Q90935[Other Products]
Molecular Weight
46,529 Da
NCBI Official Full Name
neuroserpin
NCBI Official Synonym Full Names
serpin family I member 1
NCBI Official Symbol
SERPINI1??[Similar Products]
NCBI Official Synonym Symbols
PI-12
??[Similar Products]
NCBI Protein Information
neuroserpin
UniProt Protein Name
Neuroserpin
UniProt Synonym Protein Names
Axonin-2; Peptidase inhibitor 12; PI-12; Serpin I1
Protein Family
Neuroserpin
UniProt Gene Name
SERPINI1??[Similar Products]
UniProt Synonym Gene Names
PI12; PI-12??[Similar Products]
UniProt Comments for SERPINI1
Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the ***** nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).
Research Articles on SERPINI1
1. serpin is cleaved and refolds into the relaxed state via a stressed conformer
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
